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Öğe Effects of propolis coating on antibacterial resistance of intrauterine devices(Taylor & Francis Ltd, 2024) Deniz, Alparslan; Karasu, Tunca; Idil, Neslihan; Uzun, LokmanIntrauterine devices (IUDs) are widely used in preventing fertilization as contracepting devices. In market, they are produced as T-shaped polyethylene (or propylene) and metal (especially copper) composites. Although the metal component is utilized to provide antibacterial efficacy, prolonged implantation and the presence of a wide range of bacteria flora in the intrauterine environment make IUDs susceptible to bacterial contamination, biofilm formation, and unpleasant infection. In the presented study, the propolis, a natural anti-bacterial/-viral product used for different biomedical applications, coating strategy was applied comparatively in three different ways: coating directly on metal components, coating on polymeric material, and using carrying polymer. In addition, antibacterial activity against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli) bacterial strains were investigated by both dynamic bacterial culture (bacterial inhibition activity) and biofilm (biofilm formation resistance) tests. As a result of 48 h of dynamic bacterial culture; it was determined that the antibacterial inhibition efficiency depending on propolis concentration increased up to 99.5% and 98.5% for E. coli and S. aureus, respectively. In addition, the carrying polymer allows IUDs to cover surfaces more homogeneously, as well as improve antibacterial activity. Similarly; it was determined that biofilm formation resistance was improved by 44.33% for E. coli and by 45.99% for S. aureus with both the propolis concentration and the use of carrying polymer. As a result, it has been revealed that propolis will be classified as an alternative, promising, and effective coating agent for improving antibacterial properties and biofilm formation resistance of IUDs.Öğe Evaluation of iliococcygeal fixation procedure for pelvic organ prolapse: preoperative properties and short term postoperative outcomes(2024) Köle, Emre; Hasanova, Ilaha; Şahin, Ramazan Oğuz; Ayanoglu, Esra; Aksoy, Lale; Deniz, Alparslan; Aslan, ErdoğanAim: The aim of this study was to evaluate the short-term outcomes of patients who underwent iliococcygeal fixation (ICF) for the surgical treatment of pelvic organ prolapse (POP) and to assess the safety and feasibility of the ICF procedure. Patients and Methods: Our study is retrospectively done with the data of 50 POP patients who underwent ICF in our clinic within the dates 01.04.2022 and 31.03.2024. A total of 44 women were found to be eligible for follow-up. Demographic data and pre- and post-operative clinical data at 3 months were assessed. Results: According to the findings of our study, the difference between the median duration of surgery in NSD and CS patients is statistically significant, and the duration of surgery is longer in NSD patients (80 minutes (70-85) vs 60 minutes (50 -67,5), (p<0,05)). Only one recurrence, one hematoma and infection, and one bladder injury had occurred. Conclusion: According to our study, ICF is a safe, durable and surgically feasible procedure that can be done concomitantly with other procedures. Thus, we strongly advocate this procedure until the ideal mesh is found since it avoids many serious complications of SSLF.Öğe Examination of pelvic structures of women with polycystic ovary syndrome using magnetic resonance imaging pelvimetry(2024) Köle, Emre; Özen, Selda; Deniz, Merve Erol; Kole, Merve Cakir; Deniz, Alparslan; Aksoy, Lale; Aslan, ErdoğanObjective: Our study aimed to evaluate patients with Polycystic Ovary Syndrome (PCOS) using Magnetic Resonance (MR) pelvimetry to determine if there is a specific pelvic type associated with hyperandrogenemia. Method: This study retrospectively analyzed data collected from pelvic MR imaging performed on 36 patients diagnosed with PCOS who attended the outpatient clinic of Alanya Education and Research Hospital between 2021 and 2022. All cases were of reproductive age, between 18 and 49 years, and were initially diagnosed with PCOS via ultrasound, had a history of hirsutism or amenorrhea, followed by subsequent MR imaging. A control group of 35 patients, matched for reproductive age without PCOS diagnosis, hirsutism, amenorrhea, or menstrual irregularities, who underwent MR imaging for any other reason were recruited Results: No significant differences were observed between the groups in terms of age, gravidity, parity, abortions, except for weight and Body Mass Index (BMI). Comparison of MR pelvimetry results between the groups, including pelvic inlet transverse diameter (cm), interspinous diameter (cm), midsagittal pelvic inlet anteroposterior diameter (cm), and midsagittal pelvic outlet anteroposterior diameter (cm), revealed no significant differences. Conclusion: Unfortunatelly, the results did not provide convincing evidence to prove our hypothesis. If it were, we believe, it would provide a bridge between the animal expriments and clinical studies regarding the ethiplogy of PCOS.Öğe Female Sexual Function Index Outcome After Posterior Vaginal Tightening Approach and Anterior Cervical Ring Repair when Indicated(Springer, 2025) Kole, Emre; Akar, Bertan; Deniz, Alparslan; Kole, Merve Cakir; Aslan, Erdogan; Caliskan, ErayBackgroundFemale sexual dysfunction is believed to be associated with pelvic floor dysfunction in most cases. However, correcting prolapse does not always necessarily correct sexual function. The reason for this might be secondary to disregarding anatomically relevant structures during surgical interventions. We aimed to demonstrate that posterior vaginal tightening approach avoiding anteriorly located structures, such as clitoral complex, would yield better results in terms of sexual function.MethodsFifty-seven postmenopausal women with primary complaints of vaginal laxity and Grade I and II prolapse were operated. All patients received posterior vaginal tightening operation, and a cervical ring repair was utilized when indicated (n:25). Perineal repair was done if there was any defect (n:13). Levator plication is not done in any patients. FSFI (Turkish Version) was applied to each patient prior to surgery and at 6th month postoperatively. A Likert-type scale is also utilized to assess the patient satisfaction from the procedures.ResultsAll the domains and the total score of FSFI were observed to be improved. Only the improvement in the pain domain scores was not statistically significant. Satisfaction of the patients from the surgery on a Likert scale was so as to: very satisfied 27 (47.4%), satisfied 12 (21.1%), neither satisfied nor dissatisfied 8 (14%), dissatisfied 5 (8.8%), very dissatisfied 1(1.7%).ConclusionSexual function of women with vaginal laxity can be improved when vulvovaginal erotogenic complex is not disrupted. This can be achieved via a posterior approach while maintaining successful anatomic correction of both posterior and anterior compartments.Level of Evidence IIIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Öğe Increased cesarean-section birth rates and affecting related factors(2021) Deniz, AlparslanAim: The present study aims to evaluate the opinions of physicians on increased C-section delivery rates and their coping ways working at different institutions. Method: This descriptive, cross-sectional study included a total of 200 obstetricians and gynecologists with an experience of at least 20 years chosen through simple random sampling among registered in the Republic of Turkey, Ministry of Health da-tabase. In the questionnaire, their opinions about test exams and their opinions about solutions to decrease C-section rates were investigated. Results: The majority of the participants (89.0%) responded “Strongly Agree” to the following item: “Factors other than medical causes may affect the decision for C-sec-tion”. Similarly, the majority of the physicians responded “Strongly Agree” to the item on the increase in C-section rates along with malpractices and social pressure put by the patient and her relatives(89.0% and 89.5%, respectively). For the majority of the participants (84.0% and 85.0%, respectively), the main suggestions to overcome the increased C-section delivery rates was to lower; social pressure put against the physicians by the patient and her relatives, and removal of malpractice penalties re-latedfor possible adverse outcomes during normal delivery. In this study, the majority of the physicians responded “Strongly Disagree” to the items related to the imposing penalties and granting bonuses (56.0% and 56.5%, respectively). Similarly, 81.0% of the physicians responded “Strongly Disagree” to the item stating that healthcare planners correctly interfere with the main cause of increased C-section rates. Conclusions: The most important reasons for the high cesarean rates are seen as the fear of malpractice and social pressure of physicians working in both public and private sectorsÖğe Increased Cesarean-Section Birth Rates and Affecting Related Factors(2021) Deniz, AlparslanAim: The present study aims to evaluate the opinions of physicians on increased C-section delivery rates and their coping ways working at different institutions. Method: This descriptive, cross-sectional study included a total of 200 obstetricians and gynecologists with an experience of at least 20 years chosen through simple random sampling among registered in the Republic of Turkey, Ministry of Health da-tabase. In the questionnaire, their opinions about test exams and their opinions about solutions to decrease C-section rates were investigated.Results: The majority of the participants (89.0%) responded “Strongly Agree” to the following item: “Factors other than medical causes may affect the decision for C-sec-tion”. Similarly, the majority of the physicians responded “Strongly Agree” to the item on the increase in C-section rates along with malpractices and social pressure put by the patient and her relatives(89.0% and 89.5%, respectively). For the majority of the participants (84.0% and 85.0%, respectively), the main suggestions to overcome the increased C-section delivery rates was to lower; social pressure put against the physicians by the patient and her relatives, and removal of malpractice penalties re-latedfor possible adverse outcomes during normal delivery. In this study, the majority of the physicians responded “Strongly Disagree” to the items related to the imposing penalties and granting bonuses (56.0% and 56.5%, respectively). Similarly, 81.0% of the physicians responded “Strongly Disagree” to the item stating that healthcare planners correctly interfere with the main cause of increased C-section rates.Conclusions: The most important reasons for the high cesarean rates are seen as the fear of malpractice and social pressure of physicians working in both public and private sectors.Öğe OP-14 Fetal right ventricular diverticulum a case report(2023) Güllüoğlu, Ahmet; Deniz, Alparslan; Köle, Emre; Çalışkan, Eray; Hasanova, İlahaAim We report the case of 27 years old age Turkish lady G2 P1 at 20 weeks of gestations, double test was normal, attended for routine prenatal ultrasound screening a four chamber ultrasound of the heart with right ventricular diverticulum associated with pericardial effusion. Case A 27 years old age woman at 20 weeks of gestation, came for routine second trimester ultrasound screening. Ultrasound revealed four chambers of the heart with right ventricular outpouching (right ventricular diverticula or aneurysm) associated with pericardial effusion, no other anomalies. She was explained about the ultrasound findings and referred to pediatrics cardiology, fetal cardiac echo was done, confirmed the ultrasound findings and the diagnosis of fetal right ventricular diverticulum with pericardial effusion with no other cardiac malformations. She was followed up by ultrasound at 22 weeks of gestations, which revealed same findings but the pericardial effusion increased. Follow up ultrasound at 24 weeks of gestations the fetus was intrauterine death. Discussion By reviewing literature the overall prenatal prognosis of ventricular diverticula is favorable even if associated with pericardial effusion, hence conservative management may be a reasonable option, unless there is risk of impending rupture, cardiac temponade or significant lung compression and subsequently pulmonary hypoplasia. Our case was with right ventricular diverticulum and pericardial effusion and no other cardiac malformations and the choice of conservative management was opted but the fetus died at 24 weeks of gestation. Among the therapeutic options fetal pericardiocentesis to decompress the fetal thorax to allow lung expansion and reduction of systemic venous pressure leading to reduction in the risk of pulmonary hypoplasia but the risk is considered too high especially in isolated ventricular diverticulum with pericardial effusion as pulmonary hypoplasia usually resolve with corticosteroid therapy and pericardial effusion disappears progressively in most of the cases. Conclusion The prognosis is good in isolated cases. The 10 years survival rate for the patients with ventricular diverticula is approximately 80% while the 4 years survival rate for patients with congenital ventricular anuerysm is approximately 30%. However complications include rupture, arrhythmia, thrombus formation, heart failure and infective endocarditis, therefore, monitoring is required.Öğe PolyPyrrole based-impedimetric aptasensor for selective determination of beta-HCG from urine sample(Elsevier Science Sa, 2025) Deniz, Alparslan; Karasu, Tunca; Ozgur, Erdogan; Uzun, LokmanHerein, a conjugated conducting polymer-based impedimetric aptasensor has been developed to detect beta-human chorionic gonadotropin (bHCG), the one of the important biomarkers in gynecology, from synthetic human urine samples. In this context, gold electrodes were, firstly coated with pyrrole and pyrrole-3-carboxylic acid to obtain the poly(pyrrole-pyrrole-3-carboxylic acid) [poly(Py-PyCOOH)] conductive copolymer by cyclic voltammetry (CV). Then, bHCG-specific peptide aptamer was covalently linked onto the surface via applying a well-known carbodiimide-succinimide chemistry. The sensor developed was characterized to confirm modification steps via both electrochemical methods including CV, electrochemical impedance spectroscopy (EIS), and chronoamperometry and physico-chemically via attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), atomic force microscope (AFM), and contact angle measurements (CA). The analytical performance of the sensor was evaluated in the concentration range from 1 mu g/mL to 100 mu g/mL for successful detection of bHCG even in the presence of interference agents. The results have also revealed that the sensor could be classified as a promising alternative to its benchmark commercial clinical methods due its superior properties such as cost-friendliness, easy-to-prepare, stable, robust, and selectivity / sensitivity.Öğe Pregnancy outcomes in patients with MTHFR gene polymorphism: A case series(Selçuk BAŞAK, 2020) Deniz, AlparslanAim: Based on the literature, MTHFR polymorphism is common among the general population and is controversial in terms of treatment, as it is poorly associated with pregnancy complications. In this study, we aimed to investigate the relationship between treatment and pregnancy outcomes in patients with MTHFR polymorphism.Methods: The data of 48 patients who were diagnosed with MTHFR C677T and A1298C polymorphism between June 2012 and April 2020 and followed up during their pregnancy were reviewed retrospectively. Demographic and clinical features of patients, pregnancy history, diagnosis, and perinatal complications were examined. Pre- and post-treatment clinical features of the patients were compared.Results: Comparison of pre- and post-treatment pregnancy data of the patients revealed that live birth rates were significantly higher (pre-treatment: 9.4% post-treatment: 68.7%, P=0.001) and abortion rates were significantly lower after treatment (pre-treatment: 81.2%, post-treatment: 32.1%, P=0.001). Pregnancy complications were observed in 9 (18.3%) patients. It was observed that among patients with MTHFR gene mutation, live birth rates increased by 24.12-fold and by 3.76-fold for each year of decrease in the age of conception following treatment. Conclusion: In pregnant women with MTHFR polymorphism, methionine-poor diet and medical treatment had a positive effect on pregnancy outcomes. It was also observed that among those with MTHFR gene polymorphism, young patients with MTHFR A1298C heterozygotes had the best treatment results.Öğe Serial measurement of soluble endoglin for risk assessment at the diagnosis of fetal growth restriction(2021) Erol Deniz, Merve; Deniz, Alparslan; Mendilcioğlu, İnanç; Sanhal, Cem Yaşar; Özdem, Sebahat; Küçükçetin, İkbal Özen; Kandemir, HülyaAim: In this study, we aimed to investigate the soluble endoglin (sEng) levels in pregnant women with fetal growth restriction (FGR) and to examine the possible relation of the sEng levels with the time remaining to delivery and maternal and fetal complications. Methods: A total of 42 pregnant women diagnosed with FGR were retrospectively reviewed. Using the maternal blood samples it is at the collected 24-37 gestational weeks, the sEng levels were measured. Fetal biometry measurements, umbilical artery, uterine artery, middle cerebral artery Doppler indices were documented. Results: Of all patients, 17 (40%) were diagnosed with early-onset FGR, while 25 (60%) were diagnosed with late-onset FGR. Abnormal Doppler findings were present in 25 (60%) patients. Of 42 newborns, 18 (42%) were hospitalised in the neonatal unit. The mean sEng level calculated by taking the average of the first and second blood samples was 63.24 ± 49.83 ng/mL. There was no statistically significant difference in the mean sEng levels between those who gave birth within four, three, and two weeks after the diagnosis of FGR and those who did not. There was a positive significant correlation between the mean sEng levels and systolic blood pressure (r = 0.319, P =.04). Conclusions: We did not find a statistically significant relationship between the sEng level and the time remaining to the time of delivery in pregnant women with FGR. We found no statistically significant difference in sEng level between the groups in pregnant women with fetuses with FGR with or without maternal and fetal complications.Öğe The effects of age, parity and body mass index on 50 g oral glucose tolerance test results and its predictive value in gestational diabetes mellitus(Selçuk BAŞAK, 2020) Deniz, AlparslanAim: The aim of this study was to investigate the effects of age, parity, body mass index (BMI) and maternal risk factors on 50 g oral glucose tolerance test (OGTT) positivity and to evaluate the predictive value of 50 g OGTT in the diagnosis of gestational diabetes mellitus (GDM). Methods: Medical data of pregnant women who were followed in a private obstetrics and gynecology clinic between June 2012 and April 2020 were analyzed in this retrospective cohort study. All patients underwent 50 g OGTT between 24 and 28 weeks of gestation. A 1-h postprandial venous plasma glucose cut-off of ?140 mg/dL was considered positive for OGTT and the diagnosis was confirmed by 2-h 75 g OGTT. The relationship between the GDM and OGTT results, BMI, parity, age, and other maternal risk factors was analyzed in the regression analysis. Results: A total of 323 pregnant women were included in the study. The mean age was 29.35 (5.29) years and the mean BMI was 27.23 (6.07) kg/m2. Among them, 35.9% had ?1 risk factors. The sensitivity, specificity, positive predictive value, and negative predictive value of 50 g OGTT for GDM were 100%, 80.7%, 27.5%, and 100%, respectively. Regression analysis revealed that family history of diabetes, history of GDM, and macrosomic birth increased the GDM risk by 5.73, 4.95, and 1.43 folds, respectively. Conclusion: Evaluation of advanced maternal age, pre-pregnancy BMI, and maternal risk factors is useful to predict GDM. In addition, 50 g OGTT is helpful in diagnosing GDM for both maternal and fetal health.Öğe The impact of obesity on fertility and sexual function in women of child bearing age(2022) Deniz, Alparslan; Okuyucu, MuhammedObesity and infertility are health problems that are increasing in frequency. In this study, sexual dysfunction in obese infertile women was investigated. A total of 450 women who met the inclusion criteria were recruited for the study; 150 women who had obesity without infertility, 150 women who had obesity with infertility and 150 women with normal weight but without infertility, which was the control group. The mean age of the groups were 31.3 +/- 3.9, 31.2 +/- 3.8 and 31.1 +/- 4.5, respectively. The participants were administered a sociodemographic data form, the Female Sexual Function Index (FSFI) and the Beck Depression Inventory following the measurement of body mass index (BMI). FSFI score below 26.55 was defined as sexual dysfunction. Our data were analysed using SPSS (Statistical Package for Social Sciences) 21.0 for Windows (SPSS Inc., Chicago, IL). FSFI scores were observed to be statistically significantly lower in the group of obese women with infertility than in the other two groups. In our study, sexual dysfunction was found to be statistically significantly higher in obese women with infertility compared to the control group. Therefore, healthcare professionals should evaluate infertility in obese women in terms of sexual dysfunction as well as infertility treatment.
