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    Optical coherence tomography angiography in pachychoroid spectrum diseases
    (Springer Verlag, 2018) Demirel, Sibel; Yanık, Özge; Batıoğlu, Figen; Özmert, Emin
    [No abstract available]
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    Öğe
    The recovery of microvascular status evaluated by optical coherence tomography angiography in patients after successful macular hole surgery
    (S. Karger AG, 2017) Demirel, Sibel; Değirmenci, Mehmet Fatih Kağan; Bilici, Serdar; Yanık, Özge; Batıoğlu, Figen; Özmert, Emin; Alp, Mehmet Numan
    Purpose: The aim of this study was to evaluate the optical coherence tomography angiography (OCTA) features of patients who underwent successful macular hole (MH) surgery. Methods: Nineteen patients who underwent surgery in a single eye due to MH and 13 healthy subjects as a control group were included in the study. Vascular densities, flow indexes, and the foveal avascular zone (FAZ) area in superficial and deep retinal capillary plexuses were evaluated by OCTA in the right eyes of the control group, and both the surgical and healthy fellow eyes of the patients. Results: The mean vascular densities of the superficial and deep capillary plexuses were significantly lower in the surgical eyes than in the control group (44.1 vs. 49.6%, p = 0.002, and 47.3 vs. 59.1%, p = 0.009, respectively). The mean superficial and deep capillary flow indexes were significantly lower in the surgical eyes than in the control group (0.85 vs. 1.35, p = 0.003, and 0.57 vs. 1.45, p = 0.001, respectively), while the mean superficial and deep FAZ area were significantly greater in the surgical eyes in comparison to the control group (0.55 vs. 0.32, p < 0.001, and 0.64 vs. 0.37, p = 0.001, respectively). There was no difference between the flow indexes of both layers of the healthy fellow eyes and the control group. Conclusions: These preliminary results may be an explanation for unsatisfactory visual gain after surgery, despite the successful anatomical closure of the MH. © 2017 S. Karger AG, Basel.
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    Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy
    (Springer Verlag, 2019) Demirel, Sibel; Özcan, Gökçen; Yanık, Özge; Batıoğlu, Figen; Özmert, Emin
    Purpose: To concurrently evaluate the effect of half-fluence photodynamic therapy (hf PDT) on choriocapillaris (CC) perfusion and choroidal structure in chronic central serous chorioretinopathy (CSC). Methods: This prospective study included 48 eyes of 41 patients with chronic CSC. Enhanced depth imaging optical coherence tomography and optical coherence tomography angiography (OCTA) images were analyzed. Choroidal area (CA), luminal area (LA), and stromal area (SA) were computed using Image J software. Results: One month after hf-PDT, total CA decreased to 1.312 mm 2 from 1.490 mm 2 (p < 0.001), LA decreased to 0.981 mm 2 from 1.097 mm 2 (p < 0.001), and SA decreased to 0.331 mm 2 from 0.393 mm 2 (p < 0.001). In OCTA, the CC flow in the eyes with CSC (17.75 mm 2 ) was statistically significantly lower than the fellow eyes (18.93 mm 2 ) at the baseline visit (p < 0.001). After hf-PDT, the flow in the choriocapillaris statistically significantly increased to 18.81 mm 2 at the first month (p = 0.02). Conclusions: OCTA proves that after hf-PDT a significant increase in CC perfusion occurred at first month. The decrease of the luminal areas in enhanced depth imaging optical coherence tomography is mainly due to a decrease in large-caliber vessels, which indicates that hf-PDT has an effect on larger choroidal vessels and spares CC flow. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.