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    Dental Pulp-Derived Mesenchymal Stem Cells Increase Axon Numbers in Mental Nerve Repair
    (Springer India, 2024) Gonen, Zeynep Burcin; Colpak, Halis Ali; Yay, Arzu; Gokdemir, Nur Seda; Bahar, Dilek; Canpolat, Dilek Gunay; Yalcin, Betul
    AimThe mental nerve, the extended part of the inferior alveolar nerve, is often injured during dentoalveolar, orthognathic, or tumor surgery. Numerous therapeutic interventions, including surgery and pharmacotherapy, have been used to enhance the recovery of nerve injuries. Dental pulp stem cells (DPSCs) represent an easily accessible source of adult stem cells that can be isolated from the pulp of extracted teeth. This study evaluated the effect of DPSCs on the regeneration of the mental nerve injury model of rabbits.MethodsIn this presented study, DPSCs were cultured and cell characterizations were performed by using flow cytometry and immunostainings. Bilateral mental nerve injury models of rabbits were created. In the control group (n = 10), saline was applied, and in the study group (n = 10), 2 x 106 DPSCs were applied to the repaired nerve areas. After 3 weeks, animals were killed and histological examination was obtained by using Masson's trichrome staining. An unpaired Student's t test was used when comparing the groups. Differences were considered to be statistically significant at P values of less than 0.05.ResultsThe DPSCs demonstrated a homogeneous population of mesenchymal stromal cells which expressed cluster of differentiation CD44, CD73, CD90, and CD105 and lack of CD34, CD45, and HLA-DR. Our finding clearly demonstrated that a lower number of cross-sectioned axons were founded in the control group (60.18 & PLUSMN; 2.52) compared to the study group (72.96 & PLUSMN; 2.43) (p = 0.00).ConclusionsDPSCs promote mental nerve axonal regeneration. These results suggest that DPSCs provide an important accessible source of adult stem cells for mental nerve regeneration.
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    Is Membrane Usage Really Necessary for Sinus Lifting Operation in Lateral Window Technique
    (Selcuk University, 2022) Ocak, Hakan; Demeto?lu, Umut; Gursoytrak, Burcu; Colpak, Halis Ali; Yildirim, Gülsün
    Background: Although the placement of a membrane after sinus floor augmentation promotes faster initialization of bone formation, there is evidence that these procedures may be successful and predictable without membrane barriers. The aim of this study was to investigate the presence of defects that might occur due to soft tissue invasion in the antrostomy area in two groups where membrane application was used or not used on the lateral window. Methods: Comparisons of implant survival in the groups and the amounts of bone generation were also investigated. Forty patients were selected for the study, and they were randomized into two groups in which membrane application was used (study group) or not used (control group). Twelve months following the procedure, images of the region were taken with computerized dental volumetric tomography. Results: The difference between the groups in terms of bone diameter was evaluated with an independent t test. No defect areas were found radiographically in the lateral window region in the groups. The mean bone diameter of the control group was 13.063 mm (±2.4 mm) and that of the study group was 14.10 mm (±5.8 mm). There was no significant difference between the groups in bone diameter. There were no losses in any of the implants that were placed in either group. Conclusion: The use of a membrane to close the lateral window did not play any important role in the formation of bone defects. © 2022, Selcuk University. All rights reserved.