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Öğe Estimating joint cartilage thickness on an animal model ex vivo using diffuse reflectance spectroscopy(Springer, 2019) Sırcan Küçüksayan, Aslınur; Canpolat, MuratA diffuse reflectance visible light spectroscopy method has been developed to estimate bovine cartilage thickness in real time. The system consists of a miniature UV-VIS spectrometer, a halogen tungsten light source, and an optical fiber probe including two 400-mu m diameter fibers with a center-to-center separation of 1.2 mm used to acquire the spectra. A total of four patellae were obtained from bovine just after sacrifice. In the study, ten cattle patella cartilage samples were prepared in a cylindrical shape and thinned by a 200-mu m step. Spectra were acquired from the 123 cartilage samples. Cartilage samples were divided into training and validation groups. A correlation between the thickness of the cartilage samples and the absorption spectra was obtained using the data of the training group. The relative thickness of the cartilage was estimated with an average error of 15% in the validation group using the correlation. Diffuse reflectance spectroscopy has the potential to estimate the thickness of cartilage lesions during arthroscopic evaluation of knee cartilages.Öğe Evaluation of scrotal pigmentation in infants with spectroscopic method and its correlation with 17-hydroxyprogesterone blood levels(Alanya Alaaddin Keykubat Üniversitesi, 2020) Başaran, Abdurrahman; Küçüksayan, Aslınur Sırcan; Canpolat, Murat; Güney, Sevtap VelipaşaoğluAim: To evaluate the scrotal melanin density in infants using spectrometry and to determine the correlation between spectrometric evaluations, physical examinations and blood 17-hydroxyprogesterone levels. Material and methods: A total of 40 infants were enrolled to the study, 22 of whom were diagnosed by a physician as having scrotal hyperpigmentation and 18 with normal scrotal pigmentation, who were admitted for the evaluation of prolonged jaundice. Age, gestational week, birth weight and scrotal pigmentation noted by the physician were recorded. Spectral data were acquired from scrotum and thigh. A correlation between the spectral measurements and the blood 17-hydroxyprogesterone level was determined by comparing spectral value in the wavelength range of 620-800 nm and 17-hydroxyprogesterone levels. Results: No statistically significant difference was observed between the groups who were categorized by the physician as having “hyperpigmented” or “normal” scrotal color in terms of the infant’s age, gestational week, birth weight, 17-hydroxyprogesterone level or spectrometric values. We observed a strong correlation between 17-hydroxyprogesterone levels and spectrometric values in all groups. Conclusion: This preliminary study is the first one in the literature which evaluates scrotal pigmentation with an objective spectrometric method and determines its relationship with 17-hydroxyprogesterone levels. Further studies are needed to employ this method as a non-invasive, indirect screening test for the screening of congenital adrenal hyperplasia in male infants.Öğe Histopathological and biochemical assessment of a novel diagnostic method for ovarian torsion(Taylor & Francis Ltd, 2020) Özekinci, Murat; Küçüksayan, Ertan; Erdoğan, Gülgün; Aslan, Mutay; Peştereli, Elif; Canpolat, Murat; Sırcan Küçüksayan, AslınurOvarian torsion is agynecologic emergency that affects females of all ages. Early diagnosis is important to preserve ovarian function. The false positive rate for sonographic diagnosis of ovarian torsion is 50%; therefore, a new real-time approach is required to improve diagnostic accuracy. We investigated diffuse reflectance spectroscopy for diagnosing ovarian torsion. Spectroscopic measurements were performed in vivo prior to, during and after detorsion. After bilateral oophorectomy, hemoxygenase and myeloperoxidase enzyme activity in ovarian tissue was evaluated and the tissues were examined for pathology. Spectroscopic data were compared to histopathological and biochemical data to assess the diagnostic value of the spectroscopic method for differentiating healthy and damaged ovarian tissue. We found a good correlation between spectroscopy and histopathology. We also found a correlation between the spectroscopic data and heme oxygenase enzyme activity. We found no correlation between the histopathological tissue damage score and myeloperoxidase enzyme activity. Diffuse reflectance spectroscopy may be of prognostic and diagnostic value for ovarian torsion in vivo.Öğe Investigating spectroscopic measurement of sublingual veins and tissue to estimate central venous oxygen saturation(2022) Sırcan Küçüksayan, Aslınur; Eray, Oktay; Büyükaksu, Murat; Gümüş, Birce; Dursun, Oğuz; Canpolat, MuratAbstract: BACKGROUND: Venous oxygen saturation reflects venous oxygenation status and can be used to assess treatment and prognosis in critically ill patients. A novel method that can measure central venous oxygen saturation (ScvO2) non-invasively may be beneficial and has the potential to change the management routine of critically ill patients. OBJECTIVE: The study aims to evaluate the potential of sublingual venous oxygen saturation (SsvO2) to be used in the estimation of ScvO2. METHODS: We have developed two different approaches to calculate SsvO2. In the first one, near-infrared spectroscopy (NIRS) measurements were performed directly on the sublingual veins. In the second approach, NIRS spectra were acquired from the sublingual tissue apart from the sublingual veins, and arterial oxygen saturation was measured using a pulse oximeter on the fingertip. RESULTS: Twenty-six healthy subjects were included in the study. In the first and second approaches, average SsvO2 values were 75.0% ± 1.8 and 75.8% ± 2.1, respectively. The results of the two different approaches were close to each other and similar to ScvO2 of healthy persons (> 70%). CONCLUSION: Oxygen saturation of sublingual veins has the potential to be used in intensive care units, non-invasively and in real-time, to estimate ScvO2.Öğe Noninvasive assessment of oral lesions using elastic light single-scattering spectroscopy: a pilot study(Springer, 2020) Sırcan Küçüksayan, Aslınur; Yaprak, Neslihan; Derin, Alper Tunga; Özbudak, İrem Hicran; Turhan, Murat; Canpolat, MuratPurpose: In the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo. Methods: ELSSS spectra were acquired from 52 oral lesions of 47 patients prior to surgicalbiopsy using a single optical fiber probe. The sign of the spectral slope was used as a diagnostic parameter and was compared to the histopathology findings to obtain sensitivity and specificity of the ELSSS system in differentiating between benign and malignant tissues. Results: The sign of the spectral slope was positive for the benign tissues and negative for the malignant tissues. Nine malignant lesions and one high-grade dysplasia were correctly classified as cancerous. Six out of the ten low-grade dysplasia were correctly classified as cancerous, and four of them were misclassified as benign. Thirty benign lesions were correctly classified as benign, and two were misclassified as malignant. Our results indicate that the sign of the spectral slope enables the differentiation between malignant and benign oral lesions with a sensitivity of 80% and specificity of 94%. Conclusions: ELSSS has the potential to be developed as an adjunctive screening tool in the noninvasive evaluation of oral lesions in vivo. This new diagnostic system may reduce the number of unnecessary biopsies. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
