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  • Küçük Resim
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    Are preoperative hematologic parameters predictive of intraoperative bleeding in orthognathic surgery?
    (2021) Canpolat, Dilek Günay; Çolpak, Halis Ali; Kütük, Nükhet; Alkan, Alper
    Aim: Orthognathic surgery is performed to correct dentofacial abnormalities and is generally known as a safe procedure with minimal bleeding. The purpose of this study was to evaluate whether the preoperative hematological parameters help predict intraoperative bleeding in orthognathic surgery. Material and Methods: This retrospective study was performed with patients who underwent orthognathic surgery. Patients records were evaluated in terms of the demographics (gender, age, weight), duration of the surgery, amount of intraoperative bleeding, and the preoperatively routine complete blood count (CBC) parameters, especially PLT, MPV, MPV/PLT ratio, coagulation tests (PT, a PTT, INR) and NLR were recorded from patient files. Results: The study included 101 patients with a mean age of 21.7 +/- 4.8 years. The female to mate ratio was 1.1 (52/49). The median duration of the operation was 270 minutes, ranging from 155 to 420 minutes. The amount of blood loss ranged from 90 to 820 ml in all subjects, with a median of 230 ml. The preoperative median hemoglobin value was 14.4 g/dL PT, INR, aPTT, and weight were not independent predictors for the amount of bleeding. However, the duration of the surgery was an independent predictor for the amount of bleeding (p<0.001). There was no correlation between the MPV/PLT ratio (r=0.003, p=0.972) and the neutrophil-to-lymphocyte ratio (NLR) (r--0.008, p=0.935) with the amount of bleeding (ml). Discussion: Improving possible objective markers to predict intraoperative bleeding amounts is important for avoiding and managing the intraoperative bleeding complications for the surgery team in maxillofacial surgery. The results of this study demonstrated no correlation between preoperative hematologic normal ranged parameters such as PLT, MPV, MPV/PLT, NLR, PT, PTT, INR, and intraoperative bleeding in orthognathic surgery. Thus, caution in the preparation of patients and standardized preoperative procedures are essential to avoid undesirable intraoperative bleeding in orthognathic surgery.
  • Küçük Resim
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    Comparison of the effects of ozone therapy and photobiomodulation on sciatic nerve injury in rat
    (2021) Canpolat, Dilek Günay; Yücesoy, Türker; Çolpak, Halis Ali; Çilingir-Kaya, Özlem Tuğçe; Kolbaşı, Bircan; Saraymen, Recep; Karatürk, Habip; Kütük, Nükhet; Canpolat, Mehmet
    Aim: Studies on drugs or alternative therapies are still the main treatment options for PNI. In this study, we aimed to research the effects of PBM and OT on nerve repair in a rat sciatic injury model. Material and Methods: 29 Wistar albino rats were divided into four groups: control (n = 2), sham (n = 9), OT (n = 9) and PBM (n = 9). After 30 days of surgery and treatments, tissue specimens and blood samples were taken for histological and biochemical processing. Histological evaluations were performed at light and electron microscopy levels. Myelin basic protein (MBP) and S100 from the rat serum were analysed also. Results: The OT and PBM groups had a significant increase in regeneration of the sciatic nerve in light microscopic evaluation. In the PBM and OT groups, Schwann cells (SC) around the axons and also axons with a thin myelin sheath were seen, regarded as signs of the myelination process in transmission electron microscopy (TEM) examinations. Discussion: OT and PBM both resulted in a good healing pattern for sciatic nerve injury in the rat model. Therefore, OT and PBM are considered to be simple and reliable alternative treatment methods for PNI.