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    The Investigation of Leptin (LEP) and Leptin Receptor (LEPR) Gene Variations in Obese Patients
    (Springer, 2025) Durak, Sermin; Aksoyer Sezgin, Saadet Busra; Celik, Faruk; Diramali, Murat; Yaylim, Ilhan; Gurol, Ali Osman; Cakmak, Ramazan
    Obesity is defined as a chronic public health problem that leads to deterioration in metabolic health. The leptin gene (LEP gene rs7799039) and leptin receptor (LEPR gene rs1137101) polymorphisms are thought to potentially be related to the pathophysiology of obesity and its complications. This study aimed to evaluate the role of critical gene polymorphism of the leptin gene in the pathogenesis of obesity. This study consisted of 4 groups including control (n = 49), overweight (n = 50), obese(n = 50), and morbid obesity (n = 49). Real-time polymerase chain reaction was used for distributions of genotypes. We found statistically significant results in terms of genotype distribution of LEP gene and LEPR gene polymorphisms in the study groups (p = 0,031; p < 0,001, respectively) and showed an especially significant relationship between the G allele of the LEPR gene and increased BMI. Moreover, we found that the GG genotype of the LEP gene is statistically significant in terms of BMI in the obesity and morbid obesity groups (p < 0.001). LEP and LEPR genes may serve as significant biomarkers in developing personalized treatments for obesity. Further studies with larger samples will shed light on the pathophysiology of obesity and enhance our understanding of leptin's role in obese patients.