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    Relationship of Biomarkers During Antegrade Cerebral Perfusion with Visceral Oxidative Stress and Neurological Outcomes
    (Alanya Alaaddin Keykubat Üniversitesi, 2025) Sungur, Elif Coşkun; Benli, Emre Demir; Enver, Levent; Özbek, Hamdi Mehmet; Erel, Özcan; Sarıtaş, Ahmet
    Aim: Antegrade selective cerebral perfusion (ASCP) is the standard brain preservation perfusion technique used in aortic surgery. We aimed to assess the relationship between visceral ischemia and neurological outcomes in the postoperative period by measuring oxidative stress blood biomarkers in blood samples taken from the descending aorta during antegrade selective cerebral perfusion. Patients and Methods: In this prospective observational and single-center study 54 patients were included. Group 1 (ASCP?20min) included the patients with ASCP times less than or equal to 20 minutes, and Group 2 (ASCP>20min) included the patients with ASCP times over 20 minutes. Blood samples were collected from the descending aorta and systemic blood to assess oxidative stress for all biomarkers at the end of ASCP. Blood samples were collected for other metabolic parameters in the preoperative period and postoperative day 0 (6th hour). Results: The PH and lactate levels in descending aorta and postoperative AST levels in Group 2 were statistically different in Group 1 (p < 0.001, p=0.004, p=0.012). There were statistical differences in descending aorta disulfide levels data between the groups. The ICU stay time, and the prolonged mechanical ventilator support were significantly different between the groups. Conclusion: The findings showed that parameters reflecting oxidative stress were significantly impacted by antegrade selective cerebral perfusion time, whereas new oxidative stress parameter levels were not affected. We consider the short-term antegrade selective cerebral perfusion time in the present study to be one of the main reasons for exposure to oxidative stress.