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    Investigation of Biological Effects of N- Butyl 2 Cyanoacrylate
    (Uşak Cerrahi Derneği, 2020) Karahan, Oğuz; Balkan, Mahmut; Hafız, Erhan; Khalil, Emced
    Aim: N-Butyl 2 cyanoacrylate is a frequently utilizing agent as a surgical adhesive. Biocompatibility analyses of N-Butyl 2 cyanoacrylate were evaluated in this study. Material and Method: Wistar Albino genus 16 healthy adult male (250 ± 5 gram) rats were divided into control and study groups. Determination of normal histological structure and routine physiologic observation was aimed in control group. In the study groups, 0.3 ml N-Butyl 2 cyanoacrylate injection were applied, via subcutaneous route for irritation and sensitization evaluation in the waist and back shaved group, via intramuscular route for cytotoxicity evaluation in the right femoral shaved group, and via tail vein injection for systemic toxicity evaluation in vascular administration group. Rats were sacrificed after 72. hours observation period and venous endothelium, muscular, dermal and epidermal tissues were examined histopathologically. Findings: Marked endothelial injury were detected in only intravenous administration. Extreme reaction and marked histopatholgical changes were not observed in regards of irritation, sensitization and cytotoxicity groups . Conclusion: Only intravascular administration of N-Butyl 2 cyanoacrylate, as a surgical adhesive usage, was lead advanced tissue injury in regards of local and systemic effects. However, this experimental model should be supported with clinical comprehensive studies.