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    EFFECT OF MELATONIN AND CISPLATIN ON CERVICAL CANCER CELLS: ROLE OF TRPV1 CHANNELS
    (Publ House Bulgarian Acad Sci, 2025) Ovey, Ishak Suat; Ates, Sezin
    Cisplatin, a widely used treatment for cervical cancer, and melatonin, known for enhancing the apoptotic effects of cisplatin, both play crucial roles in our study. We investigated the combined effects of these two agents on HeLa cervical cancer cells, with focus on the role of TRPV1 channels, which we found to be of significant importance. According to the treatment performed, the cell samples were divided into seven main groups: control, cisplatin, cisplatin + capsazepine (TRPV1 antagonist), melatonin, melatonin + capsazepine, cisplatin + melatonin, and cisplatin + melatonin + capsazepine. Each group was stimulated with capsaicin (TRPV1 agonist) in all analyses. We measured apoptosis, cytosolic calcium, intracellular reactive oxygen species, mitochondrial depolarization, caspase-9, and caspase-3 levels. The combined application of cisplatin and melatonin led to a significant increase in apoptosis levels, which were statistically significantly higher compared to both the control group and the group treated with cisplatin alone (p < 0.001) (Fig. 2). This notable increase underscores the potential of this combined treatment in treating cervical cancer. Our findings strongly suggest that melatonin could be a promising adjunct therapy for cisplatin-induced cervical cancer. By elevating cytosolic Ca2+ levels, promoting apoptosis, and increasing intracellular ROS levels through TRPV1 channels, melatonin indicated potential as an effective
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    Öğe
    Effects of burnout syndrome on pregnancy and the postpartum period
    (Assoc Medica Brasileira, 2025) Ates, Sezin
    OBJECTIVE: The aim of this study was to examine the prevalence of burnout among pregnant working individuals and its effects on both obstetric complications and issues that may arise in the early postpartum period. METHODS: Healthy pregnant women were questioned regarding their working life and Maslach Burnout Inventory. They were divided into two groups-burnout and non-burnout-according to the burnout score. The two groups were compared in terms of pregnancy and postpartum complications and breastfeeding. RESULTS: Burnout was identified in 164 pregnant women (54.1%). The age of the women with burnout was statistically significantly higher than that of the group without burnout. The breastfeeding rate was lower in the burnout group. In the evaluation of postpartum infective complications, 19.5% of the women with burnout and 8.6% of those without burnout developed infections, and this difference was statistically significant. CONCLUSION: It has been demonstrated that burnout increasesthe riskof infectious complications in pregnancy, reduces postpartum breastfeeding rates, and contributes to other negative outcomes.