Yazar "Aslan, Fatih" seçeneğine göre listele
Listeleniyor 1 - 20 / 26
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe An evaluation using colored doppler ultrasonography of central retinal artery hemodynamics in the healthy eye in individuals with late monocular blindness(Lippincott Williams & Wilkins, 2020) Özen, Özkan; Aslan, FatihStructural and functional changes occur in the brain after vision losses. The purpose of the present study was to investigate central retinal artery (CRA) hemodynamics in the healthy eye of individuals developing late monocular blindness (LMB) using colored Doppler ultrasonography. The CRAs of 13 healthy eyes of 13 patients with LMB and of 13 healthy individuals as a control group were evaluated in this prospective study. Peak systolic velocity, end-diastolic velocity, mean flow velocity, systolic/diastolic velocity ratio, and resistivity and pulsatility index (RI, PI) values in the CRAs were determined using colored Doppler ultrasonography in both groups. The mean age of all the individuals examined was 39.3 +/- 12.3 years, and loss of vision in the LMB patients had been present for a mean 22 +/- 13.2 years. The PSH, DHS, and mean flow velocity values in the LMB group were 13.3 +/- 2.5 cm/s, 3.1 +/- 0.8 cm/s, and 6.5 +/- 1.6 cm/s, respectively, significantly lower than in the control group at 18.6 +/- 5 cm/s, 5.5 +/- 2.8 cm/s, and 10 +/- 3.2 cm/s (P< 0.05). The PI, RI, and systolic/diastolic velocity ratio values differences in the both group were not statistically significant (P> 0.05). In conclusion, the absence of a significant difference in RI and PI values between the 2 groups revealed that vascular resistance did not develop in the CRA hemodynamics of healthy eyes of individuals with LMB, although the low velocity values showed an increase in CRA width.Öğe Can subfoveal choroidal thickness replace subjective tests in patients using tadalafil to treat erectile dysfunction?(Blackwell Publishing Ltd, 2020) Aslan, Fatih; Topçuoğlu, Murat; Öktem, Çağlar; Akkoç, Ali; Uçar, MuratWe aimed to determine the effect on choroidal thickness of daily 5 mg tadalafil use in patients with erectile dysfunction (ED) and to evaluate agreement between short form of International Index of Erectile Function (IIEF 1–5, 15) scores and choroidal thickness during follow-up. Enhanced depth imaging spectral domain–optical coherence tomography (EDI-OCT) was used to measure full choroidal thickness in the subfoveal area, choroidal thickness (CT) and small-choroidal-vessel-layer (SCVL) thickness. Thirty of the 45 patients included complete their follow-ups and exhibited medication continuity. Patients were divided into two groups, five (16.7%) with ED at any level at third-month follow-up, and 25 (83.3%) with no ED, and subgroup analysis was then performed. Median changes in SCVL thickness at first- and sixth-month follow-ups were 20.5 µm versus 9.0 ?m (p =.001) and 23.5 µm versus 12.5 µm (p =.005) in patients without and with ED respectively. The SCVL thickness increased by 20 ?m compared with the baseline level, indicating an improvement in the patient's complaints of erectile dysfunction. The level of increase in SCVL thickness can be a useful and objective guide to clinicians if they cannot be present when the IIEF questionnaire is administered. © 2020 Blackwell Verlag GmbHÖğe Clinical and radiological features of traumatic orbital emphysema cases(Alanya Alaaddin Keykubat Üniversitesi, 2020) Aslan, Fatih; Öktem, ÇağlarAim: In this study, we aimed to evaluate the clinical course and treatment requirements of orbital emphysema cases resulting from orbital trauma.Material and Method: We included the 112 orbits of 82 patients who had presented to the emergency service of our hospital between 2016 and 2019 in this retrospective study. The common feature was severe orbital trauma due to various causes and referrals to the ophthalmology department with a preliminary diagnosis of ocular or orbital damage. The orbital computerized tomography images were evaluated for orbital emphysema and a classification was performed according to the location of the air as preseptal, extraconal, intraconal and intraocular. Results: We included a total of 82 subjects consisting of 65 males and 17 females in the study. The mean age was 37.85 (3-78) years in general, 36.09 (3-78) years in the males, and 44.58 (15-78) years in the females. Emphysema was present in the preseptal area in 80 cases, the extraconal area in 26, and the intraconal area in 5 of the 112 orbits. Intraocular emphysema was detected in only a single case. The orbital compartment syndrome was not present in any of our cases.Conclusion: Orbital emphysema is a common condition in orbital trauma. It may be associated with the orbital compartment syndrome. Orbital emphysema after orbital trauma is usually a benign, self-limiting condition.Öğe Comparison of retinal vascular structure in eyes with and without amblyopia by optical coherence tomography angiography(Slack Incorporated, 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, GökhanPurpose: To evaluate the retinal vascular structure in amblyopic eyes by optical coherence tomography angiography (OCTA). Methods: Thirty-seven eyes of 37 patients with anisometric amblyopia were compared with 37 eyes of 37 age- and gender-matched control subjects by OCTA in terms of superficial capillary plexus vessel density, deep capillary plexus vessel density, and foveal avascular zone. Results: The mean age was 12 ± 4.2 years in patients with amblyopia and 13 ± 6.1 years in individuals without amblyopia. Foveal superficial capillary plexus vessel densities were 20.49% ± 3.27%, 19.70% ± 3.82%, and 19.96% ± 3.84%, and parafoveal superficial capillary plexus vessel densities were 48.50% ± 3.64%, 49.01% ± 3.33%, and 48.9% ± 2.98% in amblyopic, fellow, and control eyes, respectively. The foveal deep capillary plexus vessel densities were 18.95% ± 3.76%, 18.6% ± 4.50%, and 19.29% ± 4.01%, and parafoveal deep capillary plexus vessel densities were 51.0% ± 4.21%, 51.85% ± 4.12%, and 52.03% ± 3.57% in amblyopic, fellow, and control eyes, respectively. Superficial and deep capillary plexus vessel densities in the foveal and parafoveal areas were not significantly different between the groups (P > .05). The parafoveal area was evaluated in quadrants. In the superior quadrant, superficial and deep capillary plexus parafoveal densities were significantly lower in amblyopic eyes (P < .05). No significant difference was observed in the foveal avascular zone between the groups (P > .05). Conclusions: Although no significant vascular damage was demonstrated by OCTA in amblyopic eyes, localized defects may be specific for it. Additional studies are needed to evaluate any specific localization of vascular damage related to amblyopia. Copyright © SLACK IncorporatedÖğe Comparison of wavefront aberrations in eyes with multifocal and monofocal iols before and after Nd:YAG laser capsulotomy for posterior capsule opacification(Springer Science+Business Media B.V., 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, GökhanPurpose: The aim of this study was to compare wavefront aberrations before and after Nd:YAG capsulotomy in multifocal intraocular lens (MfIOL) and monofocal (MoIOL) pseudophakic eyes with posterior capsule opacification (PCO). Materials and methods: Wavefront aberrations were measured using a ARK-10000 topographer before and after Nd:YAG capsulotomy in eyes that underwent MfIOL or MoIOL implantation and developed PCO. Total and higher-order aberrations (HOAs) values were evaluated as root mean square (RMS). Results: The study included 64 eyes with MfIOLs (64 patients) and 72 with MoIOLs (72 patients) that developed PCO. Total RMS values before and 1 month after Nd:YAG capsulotomy were 0.863 ± 0.27 and 0.504 ± 0.24 in the MFIOL group and 0.862 ± 0.31 and 0.466 ± 0.26 in the MoIOL group, respectively. Total RMS values did not differ significantly between the groups before (p = 0.914) or 1 month after Nd:YAG laser capsulotomy (p = 0.357), but decreased significantly after Nd:YAG capsulotomy compared to baseline in both the MfIOL (p = 0.027) and MoIOL (p = 0.012) groups. HOA values before and 1 month after Nd:YAG capsulotomy were 0.546 ± 0.23 and 0.364 ± 0.19 in the MfIOL group and 0.500 ± 0.21 and 0.346 ± 0.18 in the MoIOL group, respectively. HOA values did not differ significantly before (p = 0.828) or after Nd:YAG capsulotomy (p = 0.111), while both groups showed significant reduction in HOAs after Nd:YAG capsulotomy (MfIOL: p = 0.021, MoIOL: p = 0.027). Conclusions: Nd:YAG capsulotomy reduces total and HOAs to the same extent in eyes with both MfIOLs and MoIOLs, with no significant impact of the IOL design. © 2020, Springer Nature B.V.Öğe Correlation of clinical findings with computed tomography in orbital traumas(Lippincott Williams and Wilkins, 2019) Aslan, Fatih; Özen, ÖzkanBackground: Although the eye is a well-protected organ, it is frequently affected by trauma. The timely detection of ocular injuries is extremely important. In this study, the authors evaluated the consistency between findings in computed tomography (CT) examination for orbital fractures and globe integrity and clinical findings in patients presenting to the emergency department due to orbital trauma. Methods: The authors retrospectively reviewed the files of patients presenting with orbital trauma between January 2015 and January 2018 from emergency department records. Ophthalmology consultation and follow-up notes, radiology reports, and the emergency physician's notes were reviewed. Results: During the study period, 286 patients presented to the emergency department with orbital trauma. A total of 119 eyes of 83 patients who underwent orbital CT were included in the study. Orbital bone fracture was detected in 54.6% (n = 65) of the eyes. Of these, 73.8% (n = 48) involved multiple fractures. Among all eyes, the distribution of fractures in the orbital walls was lateral wall in 41.2% (n = 49), floor in 32.8% (n = 39), medial wall in 31.1% (n = 37), and roof in 10.9% (n = 13). Multiple wall fractures were detected in 36.9% (n = 44) of the eyes. At least 1 clinical finding such as diplopia, laceration, abnormal pupillary response, hypoesthesia, and exophthalmos was observed in 47.1% (n = 56) of the eyes. This rate was 56.8% among eyes with orbital fractures and 35.2% in those without fracture. There was a statistically significant relationship between floor fractures and diplopia (P = 0.002). No significant correlations were found between the other radiological and clinical findings. Conclusion: Our study revealed a relationship between the presence of orbital fracture and eye damage. In particular, the authors found that the frequency of diplopia was significantly higher in eyes with maxillary bone fracture in the orbital floor. However, orbital CT findings other than bone fracture were not consistent with clinical findings. Copyright © 2019 Mutaz B. Habal, MD.Öğe Does adjuvant intracameral triamcinolone acetonide increase the effectiveness of phacotrabeculectomy? A case-control study(Czech Medical Association J.E. Purkyne, 2020) Aslan, Fatih; Öktem, ÇağlarAims: To investigate the effect of intracameral triamcinolone acetonide (TA) on surgical success in 5-fluorouracil (5-FU) supported primary phacotrabeculectomy (PT) cases. Material and Methods: This retrospective study included 23 eyes (study group) of 23 patients who underwent TA during PT and 26 eyes (control group) of 26 patients without TA. PT patients in the study group received 1 mg TA intraoperatively at the end of surgery. Pre-and postoperative visual acuity, intraocular pressure (IOP), and number of antiglaucoma drugs used were compared. Postoperative complications and need for 5-FU injection were evaluated for both groups. Results: Mean age was 64.1 2 ± 1.91 (48–86) years in the control group and 66.52 ± 2.02 (52–86) years in the study group (p = 0.824). Comparison of pre-and postoperative IOP values showed significant decreases in postoperative IOP levels at all-time points in both the control and study groups (p < 0.001). The only significant difference between groups was on postoperative first day (study group: 9.22 ± 1.41 mmHg; control group: 6.35 ± 2.17 mmHg, p < 0.001). Need for postoperative 5-FU injection was significantly more common in the control group (p = 0.023). Conclusion: Intracameral injection of 1 mg TA at the end of PT surgery did not yield superior results in postoperative IOP compared to PT alone, and the two groups showed similar IOP reduction. When given as an adjunct to PT, 1 mg TA suppresses anterior segment inflammation and reduces the need for 5-FU injection. © 2020, Czech Medical Association J.E. Purkyne. All rights reserved.Öğe Does pseudoexfoliation syndrome affect the choroidal response after uneventful phacoemulsification(Association for Research in Vision and Ophthalmology Inc., 2020) Aslan, Fatih; Öktem, ÇağlarPURPOSE. To examine subfoveal and peripapillary choroidal thickness changes after successful phacoemulsification in cataract cases with nonglaucomatous pseudoexfoliation syndrome (PXS). MATERIALS AND METHODS. Nineteen cataract patients with PXS and 19 without PXS were included in this prospective and interventional controlled study. Subfoveal and peripapillary choroidal thicknesses were measured before surgery and on the postoperative first day (D1), first week (W1), first month (M1), second month (M2), and third month (M3). Subfoveal choroidal thickness measurement included total subfoveal choroidal thickness (tSFCT), the small choroidal vessel layer (SF-SCVL) thickness, and the large choroidal vessel layer (SF-LCVL) thickness. RESULTS. The greatest increase in mean tSFCT compared to baseline was observed between W1 and M1 with values of 23.33 ± 2.96 ?m and 31.84 ± 2.88 ?m, respectively, for the PXS and non-PXS groups (P = 0.014). The greatest increase in SF-SCVL thickness compared with baseline occurred at M1 with values of 6.66 ± 1.97 ?m and 26.52 ± 1.92 ?m, respectively, for the PXS and non-PXS groups (P < 0.001). The peripapillary choroidal thickness only showed a significant difference between the groups at the inferior measurement point with values of 117.94 ± 14.15 ?m and 137.52 ± 34.53 ?m, respectively, for the PXS and non-PXS groups (P = 0.032). CONCLUSIONS. Cataract cases with PXS exhibited a different choroidal thickness response compared to non-PXS eyes after successful phacoemulsification. The increased choroidal thickness was particularly observed in Haller’s layer in the eyes with PXS and in the choriocapillaris and Sattler’s layer in the eyes without PXS. Copyright 2020 The Authors.Öğe Effect of neuroprotective citicoline eye drops on macular microcirculation(NLM (Medline), 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, GökhanBACKGROUND AND OBJECTIVE: To use optical coherence tomography (OCTA) examination of the retinal microvascular structures to evaluate the effect of neuroprotective eye drops (citicoline, OMK1®) administered for laser in situ keratomileusis (LASIK) surgery. PATIENTS AND METHODS: This prospective study included 45 patients treated with citicoline after LASIK and 48 patients not treated with citicoline after LASIK as a control group. In both groups, the foveal avascular zone (FAZ), retinal superficial vascular density (SVD), and deep vascular density (DVD) in the foveal and parafoveal areas were measured preoperatively and at 1 and 3 months postoperatively using OCTA. RESULTS: No significant difference was detected between the groups in terms of preoperative SVD or DVD in the foveal and parafoveal zones and all quadrants (superior, inferior, temporal, and nasal) (P?>?0.05). Similarly, no significant difference was detected between the citicoline group and control group in terms of SVD or DVD in the foveal and parafoveal zones at 1 and 3 months after LASIK (P?>?0.05). CONCLUSIONS: Despite their neuroprotective effect, topical citicoline drops had no significant effect on the superficial and deep microvascular structures of the retina or choriocapillaris.Öğe Effect of pseudoexfoliation syndrome on lamina cribrosa morphology after uneventful phacoemulsification(2022) Aslan, Fatih; Şahinoğlu Keşkek, Nedime; Altındal, Emin UtkuAim: To evaluate the behavior of the lamina cribrosa (LC) following successful phacoemulsification (PE) surgery in non-glaucomatous PXS cases with cataract. Methods: A total of 25 bilateral PXS and 56 non-PXS cataract patients were included in this prospective, interventional, and controlled study. The lamina cribrosa thickness (LCt) and anterior laminar depth (ALD) were measured horizontally and vertically from two sections using EDI-OCT. The measurements were taken preoperatively, and the LCt and ALD measurements were repeated at week one (W1), month one (M1), month two (M2), and month three (M3) postoperatively. Results: The baseline horizontal and vertical LCt values were found to be significantly thinner in the PXS group (p = 0.001, p = 0.006 respectively). The horizontal section ALD values were 463.32 ± 98.82 µm and 383.88 ± 85.8 µm (p < 0.001) for the PXS and non-PXS groups, respectively, and this significance continued during follow-up. The vertical ALD values were 469.64 ± 117.83 µm and 390.3 ± 98.1 µm (p = 0.002) in the PXS and non-PXS groups, respectively. There was no significant change in the PXS group for the depth following PE, but a statistically significant depth increase response was observed in the non-PXS group during follow-up. Conclusion: It is possible to conclude that the bending capacity of the lamina cribrosa may be lower than seen in the normal population, but we do not know how this lack of flexibility will affect the eye.Öğe Evaluation of early retinal and choroidal microvascular changes in type 2 diabetes patient without retinopathy(Gazi Eye Foundation, 2020) Çınar, Esat; Yüce, Berna; Aslan, FatihPurpose: To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM) without diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods: A total of 48 DM and 48 healthy control subjects were included. Mean superficial and deep vessel density (SVD, DVD) and flow in superficial and deep layers, choriocapillaris (CC) and FAZ area were measured by OCTA for analysis. Also, patients were categorized into two groups as high-risk (? 5 years) and low-risk (< 5 years) according to the duration of DM. Results: SVD did not change in eyes without DR, but DVD significantly decreased when compared to healthy controls (p< 0.05). Both superficial and deep layer's flow did not change in diabetic patients who had a significant enlargement in FAZ area. CC flow area and CC thickness did not change in DM patients (p> 0.05). The mean DVD and FAZ area were correlated with HbA1c levels and the duration of DM. Comparison between the high-risk (20 patients) and low-risk groups (28 patients) revealed significant difference in superficial and deep layer's flow, CC and FAZ area (p<0.05). Also, SVD and DVD measurements of the DM patients were significantly different between high-risk and low-risk groups for all macular regions (p<0.05 for all). Conclusions: OCTA can show the damage in patients without any clinically significant DR before the clinical manifestation in diabetic patients. Our results suggested that OCTA might be a promising tool for periodic screening of diabetic patients without DR. © 2020 Gazi Eye Foundation. All rights reserved.Öğe Evaluation of patients presenting to the ophthalmology department of a tertiary hospital for nonemergency reasons during the covid-19 pandemic(2020) Aslan, Fatih; Öktem, ÇağlarObjective: To evaluate changes in the demographic and diagnostic distribution of patients presenting to the ophthalmology department during the COVID-19 pandemic, compared to the pre-pandemic period. Methods: The study included patients who made outpatient appointments in our ophthalmology department. The COVID-19 group (CovG) comprised patients who presented between April 15 and May 15, 2020, the 30-day period with the highest daily number of new cases in Turkey. The control group (CG) was obtained by randomization through a computer program from among 2 245 patients who applied in the same period of the previous year. The patients’ presenting complaint(s), diagnostic(s) and demographic information’s were collected from a database, with all identifying information concealed. For patients who presented more than once, their initial complaint and diagnoses were analyzed. Results: The study included a total of 400 patients: 200 in the CovG and 200 in the CG. Mean ages in the CovG and CG were 41.23 ± 14.48 and 48.20 ± 17.49 years, respectively (p < 0.001). The female to male patient ratio was 0.53 in the CovG and 0.83 in the CG (p = 0.032). There were fewer university graduates compared to other education levels among the patients who presented during the pandemic (p = 0.013). During the COVID-19 pandemic, there was no increase in presentation frequency for any ocular disease compared to the previous year. The only statistical decrease in patient application complaints was observed in reading difficultness (11 % in CovG vs. 37 % in CG; p < 0.001). Presentations due to dry eye (DE) and allergic conjunctivitis (AC) were similar to the same period of the year (p = 0.303 and p = 0.550, respectively). At least 1 chronic ocular disease was present in 25 % of the CovG and 45.5 % of the CG (p < 0.001). A statistically significant decrease was observed in CovG for age-related macular degeneration and glaucoma in the diagnoses made at the end of the examination (p = 0.001 and p < 0.001, respectively). Conclusion: During the first peak of the COVID-19 pandemic in Turkey, the most common outpatient presentations to the ophthalmology department were for the diagnoses of DE and AC. During peak pandemic period, elderly patients, women and academically trained patients significantly reduced their visits to the Eye Clinic. The reduction in presentation of patients with glaucoma and age-related macular degeneration may be due to the longterm treatment planning for these patients and the social isolation measures issued for the older population. These patients should be encouraged to use video consultation / telemedicine in eye patients at risk of vision loss.Öğe Evaluation of retinal and choroidal microvascular changes in patients who received hydroxychloroquine by optical coherence tomography angiography(NLM (Medline), 2021) Çınar, Esat; Yüce, Berna; Aslan, FatihPURPOSE: The aim of the study is to evaluate the retinal and choroidal microvascular changes via optical coherence tomography angiography in patients who received hydroxy-chloroquine. METHODS: In total, 28 eyes of 28 patients (24 females, and 4 males) receiving treatment with hydroxy-chloroquine were assessed in this cross-sectional cohort study (hydroxychloroquine group). The high-and low-risk groups consisted of patients receiving hydroxychloroquine for ?5 years (14 eyes of 28 patients) and <5 years (14 eyes of 28 patients), respectively. A total of 28 age- and gender-matched volunteers were enrolled as the control group. The macular flow area (superficial, deep, and choriocapillaris), superficial and deep vessel density, foveal avascular zone area, central foveal thickness, and subfoveal choroidal thickness parameters were measured by optical coherence tomography angiography. RESULTS: The mean age of the 28 patients who received hydroxychloroquine and the 28 age-matched controls was 45.5 ± 11.1 years (range: 29-70 years) and 44.5 ± 13.9 years (range: 28-70 years), respectively. In patients who received hydroxychloroquine, the values for the superficial, deep, and choriocapillaris macular flow areas were 13.578 ± 0.30, 13.196 ± 0.31, and 17.617 ± 0.42, respectively. In controls, these values were 16.407 ± 0.95, 13.857 ± 0.31, and 18.975 ± 0.76, respectively (p<0.05 for all). The superficial, deep, and cho-riocapillaris flow areas were significantly smaller in patients who received hydroxychloroquine than those in controls (p<0.05 for all). Superficial and deep vessel densities were significantly reduced in patients who received hydroxychlo-roquine in all regions (i.e., foveal, parafoveal, temporal, superior, nasal, and inferior) (p<0.05 for all). Moreover, significant difference was observed between the groups in the foveal avascular zone area (superficial and deep), central foveal thickness, and subfoveal choroidal thickness (p<0.05 for all). CONCLUSIONS: Retinochoroidal microvascular flow and vessel density of the macular area were significantly decreased in patients who received hydroxychloroquine. Hy-droxychloroquine may damage the retinochoroidal mi-cro-vascular architecture. Optical coherence tomography angiography may contribute to the early detection of hy-dro-xychloroquine-induced retinal toxicity.Öğe Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography(Springer, 2020) Yüce, Berna; Çınar, Esat; Aslan, Fatih; Küçükerdönmez, CemPurpose To evaluate the retinal vascular structure before and after the epiretinal membrane (ERM) surgery by optical coherence tomography angiography (OCTA). Methods Twenty-two eyes with ERM (study eyes) had been evaluated by OCTA for superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD) at foveal and parafoveal regions and foveal avascular zone (FAZ) before and after ERM removal surgery. Twenty-two fellow eyes were selected as control group. Results Preoperative VD of SCP and DCP were significantly lower in ERM eyes than in controls in both foveal and parafoveal areas (p < 0.05, for all). The difference regressed in SCP (fovea: 18.04 +/- 3.1 vs 19.98 +/- 18p = 0.002 and parafovea: 47.33 +/- 3.54 vs 49.71 +/- 28p = 0.001), but persisted in DCP (fovea: 17.25 +/- 3.52 vs 17.57 +/- 4.01p = 0.856 and parafovea: 50.12 +/- 4.35 vs 50.93 +/- 3.24p = 0.791) in study eyes, postoperatively. Superficial and deep FAZ areas were significantly smaller in study eyes than controls. Postoperatively, superficial FAZ area enlarged (0.288 +/- 0.10 vs 0.307 +/- 0.08p = 0.012), whereas deep FAZ area did not (0.324 +/- 0.09 vs 0.338 +/- 0.07p = 0.435). FAZ area was correlated with the best-corrected visual acuity in ERM eyes. Conclusion Vascular damage in SCP and DCP was demonstrated by OCTA in eyes with ERM. ERM removal surgery mainly improves superficial changes caused by ERM. Changes in deep retinal flow may be associated with visual outcomes after ERM removal surgery.Öğe Evaluation of the effect of a novel ?3-adrenergic agonist on choroidal vascularity(2021) Topçuoğlu, Murat; Aslan, FatihPURPOSE. To determine the effect of the new ?3-agonist (mirabegron), which is used for overactive bladder (OAB) treatment, on central retinal thickness (CRT) and choroidal vascularity. MATERIAL AND METHODS. The 26 eyes of 26 cases using 50 mg tablet mirabegron once per day for OAB were included in this prospective case control study. The CRT, choroidal thickness (ChT), and choroidal vascularity were measured at baseline, week 1 (W1), month 1 (M1), month 2 (M2), and month 3 (M3). Subfoveal ChT measurement included the total subfoveal choroidal thickness (SFCT), and the small and large choroidal vessel layer (SCVL and LCVL) thickness. The total choroidal area (TCA), lumen area (LA), stromal area (SA), stroma/lumen ratio, and choroidal vascularity index (CVI) were measured with the Image-J software. RESULTS. The largest SFCT increase compared to baseline was at M1 (26.8 ± 40.8 ?m, P = 0.001). The subfoveal SCVL thickness showed a significant decrease at M2 and M3 (?6.0 ± 8.9 ?m, P = 0.002; ?7.8 ± 13.4 ?m, P = 0.046, respectively). LCVL thickness showed a significant increase at W1, M1, and M2, with the largest at M1. CVI showed a significant increase at M1, M2, and M3 (P < 0.05 for all). The TCA, LA, and SA showed a significant increasing trend at all follow-up periods. LA/SA decreased at W1 because of stromal expansion but increased at M3 with more prominent vascular dilatation. CRT values showed no significant change. CONCLUSIONS. Mirabegron had a significant effect on choroidal thickness. Choroidal vascular response is in the form of narrowing in the choriocapillaris and enlargement in the Haller's layer.Öğe Influence Of Pregnancy On Neuromyelitis Optica From An Ophthalmological Point Of View. A Case Report(2022) Aslan, Fatih; Tuğba Çimşir, Meral; Özdemir Öktem, EceNeuromyelitis Optica (NMO, Devic’s disease) is a rare demyelinating disease of the central nervous system, leading to optic neuritis and transverse myelitis. The clinical course of the disease and ocular changes in pregnancy are still not well known. Here we present the subclinical ophthalmological changes which were evaluated by spectral domain optical coherence tomography (SD-OCT) during the 39 weeks’ gestation and postpartum period in a pregnant woman with a diagnosis of NMO. In addition, we present the obstetric and neurological course of our patient and review the literature. A 30-year-old female with a history of NMO was ophthalmologically examined and SD-OCT was performed periodically every trimester to observe the effects of pregnancy on the disease course. No ophthalmological changes were observed during the pregnancy and postpartum period. Caesarean delivery was preferred due to obstetric indication. The patient was discharged on the second day of the postpartum period.Öğe Intraocular lens tilt and decentration after Nd:YAG laser posterior capsulotomy: Femtosecond laser capsulorhexis versus manual capsulorhexis(Elsevier Inc., 2019) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan; Küçükerdönmez, CemPurpose: To compare intraocular lens (IOL) tilt and decentration after Nd:YAG laser posterior capsulotomy in eyes that had femtosecond laser–assisted capsulotomy versus manual capsulorhexis. Setting: Ekol Eye Hospital, Izmir, Turkey. Design: Retrospective case series. Methods: Intraocular lens decentration and angle of tilt were measured using a Scheimpflug camera before and 1 month after Nd:YAG capsulotomy. Results: Eighteen eyes had a femtosecond laser–assisted capsulotomy and 25 eyes a manual capsulorhexis. The mean age was 58.2 years ± 10.2 (SD) (range 44 to 69 years) and 60.6 ± 8.3 years (range 45 to 70 years), respectively. Before capsulotomy, the angle of tilt and decentration at both meridians did not differ significantly between the 2 groups (P > .05). After capsulotomy, the angle of tilt was significantly decreased in both groups (femtosecond: vertical 1.5 degrees and horizontal 1.2 degrees; manual: vertical 1.1 degrees and horizontal) and decentration was significantly increased (femtosecond: vertical 0.085 mm and horizontal 0.096 mm; manual: vertical 0.2 mm and horizontal 0.2 mm) at both meridians (P < .05). After capsulotomy, all tilt and decentration parameters were significantly different between the 2 groups (P < .05) except decentration on the horizontal meridian (P = .669). Conclusions: Nd:YAG posterior capsulotomy performed after femtosecond laser–assisted capsulotomy resulted in better mechanical stability of the IOL. This suggests that a femtosecond laser–created capsulotomy better maintains a proper IOL position. Although the differences were statistically significant, the tilt and decentration values were small and might not be clinically significant. © 2019 ASCRS and ESCRSÖğe Kapama tedavisi alan ve almayan ambliyop çocuklarda retina vasküler yapısının optik koherans tomografi anjiyografi ile karşılaştırılması(2019) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan; Küçükerdönmez, Fehmi CemAmaç: Kapama tedavisi alan ambliyop çocuklar ile kapama tedavisi almayan ambliyop çocuklarda retina yüzeyel kapiller pleksus ve derin kapiller pleksus yapısını optik koherans tomografi anjiyografi ile değerlendirmek. Gereç ve Yöntem: Kesitsel vaka kontrollü yapılan bu çalışmada kapama tedavisi alan 20 anizometropik ambliyop hastanın 20 ambliyop gözü (Grup 1) ve anizometropik ambliyopisi bulunan ancak hiç kapama tedavisi yapılmamış 25 hastanın 25 ambliyop gözü (Grup 2) ve sağlıklı 45 hastanın 45 gözü (kontrol grubu; Grup 3) çalışmaya dahil edildi. Tüm gözlerde 3x3 mm alan haritasında optik koherans tomografi anjiyografi ile ölçülen retinanın yüzeyel ve derin vasküler yapı dansitesi ve foveal avasküler alan karşılaştırıldı. Bulgular: Grup 1, 2 ve 3’teki hastaların yaşları sıra ile 6,1 ± 1,02, 5,9 ± 0,92 ve 6,0 ± 0,93 idi (p >0,05). Foveal alanda yüzeyel kapiller pleksus vasküler dansitesi Grup 1, 2 ve 3’te sırası ile 20,45 ± 3,73, 21,39 ± 3,91, 20,24 ± 3,61 olarak ölçülürken, derin kapiller pleksus vasküler dansitesi 18,39 ± 3,05, 19,85± 4,38, 19,62 ± 5,53 olarak ölçüldü. Parafoveal alanda yüzeyel kapiller pleksus vasküler dansitesi Grup 1, 2 ve 3’te sırası ile 49,01 ± 4,84, 48,45 ± 3,01, 48,88 ± 3,76 olarak ölçülürken, derin kapiller pleksus vasküler dansitesi 52,54 ± 4,27, 49,45 ± 3,59, 52,01 ± 3,37 olarak ölçüldü. Foveal ve parafoveal alanda ne yüzeyel kapiller pleksus ne de derin kapiller pleksus tabakasında vasküler dansite açısından anlamlı fark görülmedi. Foveal ve parafoveal alanda yapılan foveal avasküler alan ölçümlerinde gruplar arasında anlamlı fark görülmedi. Sonuç: Retina vasküler yapısı, kapama tedavisi alan ambliyop gözler ile kapama tedavisi almayan ambliyop gözler arasında belirgin bir farklılık göstermemektedirÖğe LASIK cerrahisinde menteşe pozisyonunun Kornea duyarlılığına ve kuru göze etkisi(2019) Çınar, Esat; Küçükerdönmez, Fehmi Cem; Erbakan, Gökhan; Yüce, Berna; Aslan, FatihAmaç: Bu çalışmanın amacı farklı menteşe pozisyonları ile yapılan LASIK cerrahisinin kornea duyarlılığına ve kuru göze etkisini incelemektir. Gereç ve Yöntem: Çalışmamız prospektif, randomize vaka kontrollü bir çalışmadır. 104 hastanın randomize seçilen bir gözüne IntraLase femto saniye lazer kullanılarak nazal menteşeli flep açılırken (104 göz) diğer gözüne (104 göz) superior menteşeli flep ile miyopik LASIK cerrahisi yapıldı. Cochet-Bonnet esteziometresi ile kornea duyusu, Schirmer testi, gözyaşı kırılma zamanı tüm hastalarda ameliyat öncesi, ameliyat sonrası 1. hafta, 1, 3 ve 6. ay ölçümleri yapıldı. Bulgular: Kornea duyarlılığı ameliyat öncesi değerlere göre hem nazal hem de superior flep açılan hastalarda 3 ay boyunca azalmış olarak ölçülürken (p<.0001), 6. ay değerlerinde her iki menteşe pozisyonunda ameliyat öncesi değerler ile anlamlı fark görülmedi. Nazal menteşeli flep yapılan hastalar ile superior menteşeli hastalar karşılaştırıldığında ameliyat sonrası 1 ay boyunca korneal duyarlılık değerleri arasında anlamlı fark görülürken, 3. ve 6. ay değerleri arasında anlamlı fark görülmedi. Schirmer testi ve gözyaşı kırılma zamanı testleri ameliyat öncesindeki değerler ile karşılaştırıldığında her iki menteşe pozisyonunda 3 ay boyunca fark anlamlı iken, 6. ay değerleri arasında fark anlamlı değildi. Her iki menteşe pozisyonları Schirmer testi ve gözyaşı kırılma zamanı testleri açısından karşılaştırıldığında tüm takip süresince aradaki fark anlamlı değildi. Sonuç: Nazal menteşeli flep ile yapılan LASIK cerrahileri kornea duyarlılığı bakımından superior menteşeli fleplere göre daha üstündür ancak gözyaşı testleri açısından her iki menteşe pozisyonu arasında fark yoktur.Öğe Morphometric evaluation of cerebellar structures in late monocular blindness(Springer, 2020) Özen, Özkan; Aslan, FatihBackground Only a few studies have investigated structural and functional changes in monocular blind individuals. Our aim in this study was to segmentally investigate the cerebellar structures of subjects with late-onset monocular blindness (LMB) using a Voxel-based volumetric analysis system. Methods The segmental volumetric values, cortical thickness, gray matter volumes and percentage ratios of the cerebellar lobules of individuals with LMB due to trauma and in healthy individuals with bilateral sight as the control group were calculated at the volBrain CERES 1.0 website () by using brain 3D fast spoiled gradient recall acquisition in steady-state (3D T1 FSPGR) MRI sequence images in our prospective study. Results We studied 11 subjects with LMB (8 males/3 females) and 11 healthy control subjects (8 males/3 females). The mean age was 41.45 +/- 14.15 and 40 +/- 11.11 years, respectively (p > 0.05). The mean duration of the LMB status was 20.8 +/- 11.2 years. Cerebellar lobule crus II volume and cerebellar lobule VIIB/VIIIA volume/percentage were higher in the LMB group, and mean cerebellar cortical thickness, cerebellar lobule VI-cerebellar lobule crus I-II cortical thickness, and cerebellar lobule VI gray matter volume values were lower in the LMB group (p < 0.05). Conclusion In this study, cerebellar lobule VIIB/VIIIA volume/total percent ratio, cerebellar cortical thickness and cerebellar gray matter volume in the LMB group were found to be different from the control group. To our knowledge, this is the first study to report cerebellar anatomical changes in patients with LMB.
