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    Is increased activator protein 1 in cerebrospinal fluid as a potential biomarker that distinguishes idiopathic intracranial from sclerosis?
    (Aepress Sro, 2024) Karabork, Seyda; Celik, Humeyra; Dursun, Ali Dogan; Ankarali, Handan; Turkoglu, Sule Aydin
    OBJECTIVES: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein -1 (AP -1) was evaluated with its potential to differentiate both diseases. BACKGROUND: The aim of this study was to investigate the use of AP -1 as biomarkers for the discrimination of IIH and MS. METHODS: AP -1, TNF-alpha, and IL -6 protein values in the CSF of the cases were evaluated by the ELISA method. The numerical measures of the groups and the ability of AP -1 to distinguish the groups were analyzed with the ROC curve. RESULTS: There was no difference between the groups in CSF TNF-alpha, IL -6, CSF, and serum biochemistry analyses. However, it was determined that the AP -1 concentration (pg/ml) was significantly higher in the IIH group, the sensitivity of AP -1 in separating those with IIH was 75%, and the specificity in separating those with MS was 60% in those with an AP -1 concentration of 606.5 and above. CONCLUSION: According to our results, the fact that CSF TNF-alpha and IL -6 values did not differ in IIH compared to MS revealed that IIH could not methodologically control MS, and AP -1 was a supportive parameter in differentiating both diseases (Tab. 2, Fig. 1, Ref. 31) . Text in PDF www.elis.sk
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    Modelling pelvic and lower extremity bone measurements for individual identification: a radiological study
    (Taylor & Francis Ltd, 2025) Sertel Meyvaci, Seda; Ankarali, Handan; Celik, Ilhan; Celik, Beyza
    This study aimed to investigate the relationships between pelvic and lower extremity bone measurements and to develop predictive models. Orthorontgenographic images of 200 Turkish individuals (100 females, 100 males) aged >18 were analysed. Ten pelvic and six lower extremity measurements were taken. Sex and side differences were assessed using t-tests. Consistency between sides was evaluated with intraclass correlation coefficients, associations between variables were examined using Pearson correlation. Canonical correlation and multiple regression analyses were performed to explore multivariate relationships between pelvic and lower extremity dimensions. Most measurements showed significant sex differences. Stronger associations between pelvic and lower extremity dimensions were observed in females. Certain parameters were identified as notable contributors, specifically MCh (mean right and left coxa height) and P10 (the widest distance between the linea terminalis) in females, and MChv (mean right and left coxa maximum vertical height) and P10 (the widest distance between the linea terminalis) in males. The findings of this study demonstrate that pelvic measurements can serve as predictors of lower extremity lengths. These results hold particular relevance in forensic contexts, where they may assist in the matching of bones in cases of incomplete or commingled skeletal remains, thereby providing valuable support for anthropological identification practices.