Yazar "Alpay, Ali Seydi" seçeneğine göre listele

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    Effect of serum adropin levels on circulating endothelial dysfunction biomarkers in COVID-19 patients
    (2023) Gunesacar, Ramazan; Eksi, Durkadin Demir; Alpay, Ali Seydi; Hanikoglu, Ferhat; Erdogan, Haluk
    Purpose: Several studies show that the symptoms of severe COVID-19 infection reflect the clinical phenotype of endothelial dysfunction and share common pathophysiological mechanisms with endothelial dysfunction. Therefore, the aim of the study was to investigate the effect of serum adropin levels on endothelial dysfunction biomarkers and determine whether adropin could be a new biomarker for COVID-19. Materials and Methods: The study included 40 patients with mild/moderate COVID-19, 48 patients with severe/critical COVID-19, and 37 controls. Serum adropin and circulating biomarkers of endothelial dysfunction including asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS), soluble intercellular adhesion molecule-1 (sICAM-1) and plasminogen activator inhibitor-1 (PAI-1) levels were determined by micro-ELISA. Results: Serum adropin levels were found to be significantly higher in COVID-19 patients (165.2±11.49 pg/ml) than in controls (85.46±12.08 pg/ml). Serum adropin levels of patients with severe/critical symptoms (194±16.23 pg/ml) were significantly higher than the patients with mild/moderate symptoms (130.6 ±14.53). In addition, serum ADMA, eNOS, and, ET-1 levels were significantly higher in the COVID-19 subjects (150.5±8.67 ng/ml, 172.4±14.01 pg/ml, 159.3±10.19 pg/ml, respectively) than that those in the controls (104.5±9.182 ng/ml, 141.4±17.74 pg/ml, 100.1±11.37 pg/ml, respectively). Significant positive correlations were found between adropin and ADMA, eNOS, ET-1, sICAM-1, and PAI-1 levels in the patients. Conclusion: We suggest that adropin may be a new potential biomarker for COVID-19 and an important molecule in restoring endothelial cell damage. Positive correlations between serum adropin levels and ADMA, eNOS, ET-1, sICAM-1 and PAI-1 levels in patients suggest that adropin may compensate for damage to endothelial cells.
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    Öğe
    Effect of serum adropin levels on circulating endothelial dysfunction biomarkers in COVID-19 patients
    (Cukurova Univ, Fac Medicine, 2023) Gunesacar, Ramazan; Eksi, Durkadin Demir; Alpay, Ali Seydi; Hanikoglu, Ferhat; Erdogan, Haluk
    Purpose: Several studies show that the symptoms of severe COVID-19 infection reflect the clinical phenotype of endothelial dysfunction and share common pathophysiological mechanisms with endothelial dysfunction. Therefore, the aim of the study was to investigate the effect of serum adropin levels on endothelial dysfunction biomarkers and determine whether adropin could be a new biomarker for COVID-19.Materials and Methods: The study included 40 patients with mild/moderate COVID-19, 48 patients with severe/critical COVID-19, and 37 controls. Serum adropin and circulating biomarkers of endothelial dysfunction including asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS), soluble intercellular adhesion molecule-1 (sICAM-1) and plasminogen activator inhibitor-1 (PAI-1) levels were determined by micro-ELISA. Results: Serum adropin levels were found to be significantly higher in COVID-19 patients (165.2 & PLUSMN;11.49 pg/ml) than in controls (85.46 & PLUSMN;12.08 pg/ml). Serum adropin levels of patients with severe/critical symptoms (194 & PLUSMN;16.23 pg/ml) were significantly higher than the patients with mild/moderate symptoms (130.6 & PLUSMN;14.53). In addition, serum ADMA, eNOS, and, ET-1 levels were significantly higher in the COVID-19 subjects (150.5 & PLUSMN;8.67 ng/ml, 172.4 & PLUSMN;14.01 pg/ml, 159.3 & PLUSMN;10.19 pg/ml, respectively) than that those in the controls (104.5 & PLUSMN;9.182 ng/ml, 141.4 & PLUSMN;17.74 pg/ml, 100.1 & PLUSMN;11.37 pg/ml, respectively). Significant positive correlations were found between adropin and ADMA, eNOS, ET-1, sICAM-1, and PAI-1 levels in the patients. Conclusion: We suggest that adropin may be a new potential biomarker for COVID-19 and an important molecule in restoring endothelial cell damage. Positive correlations between serum adropin levels and ADMA, eNOS, ET-1, sICAM-1 and PAI-1 levels in patients suggest that adropin may compensate for damage to endothelial cells.
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    Öğe
    Immunization Status in Hospitalized Patients With Diagnosis of Covid-19
    (Aydin Adnan Menderes University, 2023) Alpay, Ali Seydi; Erdoğan, Haluk; Erdoğan, Aşkın; Özen, Naciye
    Objective: COVID-19 (Coronavirus disease 2019) is an acute respiratory disease. Studies conducted with the ongoing vaccine implementations all over the world have shown that vaccination significantly reduces hospitalization in the intensive care unit (ICU) due to COVID-19 disease. In this study, it was aimed to examine the relationship between the vaccination status of patients diagnosed with COVID-19 and the severity of the disease in our hospital.Methods: A cross-sectional study was conducted by questioning the vaccination status of patients hospitalized with the diagnosis of COVID-19 in Alanya Aladdin Keykubat University Education and Research Hospital on 25.08.2021. Information such as the risk factors, vaccination status, and length of hospital stay of the patients at the time of admission were recorded in the prepared forms.Results: Only one fourth of the patients were fully vaccinated. It was observed that 56.1% of the patients were not vaccinated against COVID-19. It was observed that 76.1% of the 15-49 age group and 37% of the 65 and older patient group were unvaccinated (p<0.05). The mean hospital stay was 8 days in fully vaccinated patients, 10 days in unvaccinated patients, 14 days in vaccinated patients who were under-vaccinated and required a booster dose (p<0.05). The mean age of the patients hospitalized in the ward was 54.19±18.34, in the ICU was 61.29±16.18 (p<0.05). Conclusion: In fully vaccinated patients, the length of hospital stay was short and ICU hospitalization rates were low. The fact that about a quarter of the patients are fully vaccinated suggests the possibility of variant viruses that escaped the vaccine.