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    Öğe
    Donmuş embriyo transferi yapılan hastalarda D Vitamini düzeylerinin gebelik sonuçlarına etkisi
    (Kocaeli University, 2023) Köle, Merve Çakır; Köle, Emre; Görgülü, Gökşen; Candan, Barış; Güllüoğlu, Ahmet; Doğer, Emek; Aksoy, Lale
    Amaç: Donmuş embriyo transferi yapılan infertil hastalarda 25-OH vitamin D’nin gebelik sonuçlarına etkisini değerlendirmek. Yöntem: Kocaeli Üniversitesi Tıp Fakültesi Hastanesi, Üremeye Yardımcı Teknikler Merkezinde prospektif -tek kör olarak yürütülen bu çalışmada donmuş embriyo transferi (DET) yapılması planlanan 276 infertil olgunun serum 25-OH vitamin D düzeyleri tedavi başlangıcında elde edildi. 25-OH-D vitamini seviyelerinin yetmezlik seviyesinde düşük olduğu olgular (
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    Öğe
    Evaluation of iliococcygeal fixation procedure for pelvic organ prolapse: preoperative properties and short term postoperative outcomes
    (2024) Köle, Emre; Hasanova, Ilaha; Şahin, Ramazan Oğuz; Ayanoglu, Esra; Aksoy, Lale; Deniz, Alparslan; Aslan, Erdoğan
    Aim: The aim of this study was to evaluate the short-term outcomes of patients who underwent iliococcygeal fixation (ICF) for the surgical treatment of pelvic organ prolapse (POP) and to assess the safety and feasibility of the ICF procedure. Patients and Methods: Our study is retrospectively done with the data of 50 POP patients who underwent ICF in our clinic within the dates 01.04.2022 and 31.03.2024. A total of 44 women were found to be eligible for follow-up. Demographic data and pre- and post-operative clinical data at 3 months were assessed. Results: According to the findings of our study, the difference between the median duration of surgery in NSD and CS patients is statistically significant, and the duration of surgery is longer in NSD patients (80 minutes (70-85) vs 60 minutes (50 -67,5), (p<0,05)). Only one recurrence, one hematoma and infection, and one bladder injury had occurred. Conclusion: According to our study, ICF is a safe, durable and surgically feasible procedure that can be done concomitantly with other procedures. Thus, we strongly advocate this procedure until the ideal mesh is found since it avoids many serious complications of SSLF.
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    Öğe
    Examination of pelvic structures of women with polycystic ovary syndrome using magnetic resonance imaging pelvimetry
    (2024) Köle, Emre; Özen, Selda; Deniz, Merve Erol; Kole, Merve Cakir; Deniz, Alparslan; Aksoy, Lale; Aslan, Erdoğan
    Objective: Our study aimed to evaluate patients with Polycystic Ovary Syndrome (PCOS) using Magnetic Resonance (MR) pelvimetry to determine if there is a specific pelvic type associated with hyperandrogenemia. Method: This study retrospectively analyzed data collected from pelvic MR imaging performed on 36 patients diagnosed with PCOS who attended the outpatient clinic of Alanya Education and Research Hospital between 2021 and 2022. All cases were of reproductive age, between 18 and 49 years, and were initially diagnosed with PCOS via ultrasound, had a history of hirsutism or amenorrhea, followed by subsequent MR imaging. A control group of 35 patients, matched for reproductive age without PCOS diagnosis, hirsutism, amenorrhea, or menstrual irregularities, who underwent MR imaging for any other reason were recruited Results: No significant differences were observed between the groups in terms of age, gravidity, parity, abortions, except for weight and Body Mass Index (BMI). Comparison of MR pelvimetry results between the groups, including pelvic inlet transverse diameter (cm), interspinous diameter (cm), midsagittal pelvic inlet anteroposterior diameter (cm), and midsagittal pelvic outlet anteroposterior diameter (cm), revealed no significant differences. Conclusion: Unfortunatelly, the results did not provide convincing evidence to prove our hypothesis. If it were, we believe, it would provide a bridge between the animal expriments and clinical studies regarding the ethiplogy of PCOS.
  • Küçük Resim
    Öğe
    hCG Administration in Luteal Rescue: Intracavitary or Subcutaneously in Agonist Induced Ovulation in IVF Cycles
    (2023) Aksoy, Lale; Doğer, Emek; Köle, Merve Çakır; Köle, Emre; Aksoy, Hale; Aslan, Erdoğan
    result in the cancellation of the cycle and be fatal in 3 women out of 100,000. The aim of this study is to compare the admission of human chorionic gonadotropin (hCG) subcutaneously versus intracavitary during ovum pick-up (OPU) in agonist induced ovulation in IVF cycles in terms of pregnancy outcomes. Methods: This study was carried out in Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology Assisted Reproductive Techniques Clinic as a retrospective study. 157 patients who underwent IVF treatment between January 2018 and February 2020, with ?25 follicles detected in ultrasound and 1 mg of triptorelin acetate was administered for ovulation trigger, and 36 hours later of whom ?20 oocytes were obtained in OPU were enrolled in this study. 109 patients who were administered 1500 IU of hCG subcutaneously belonged to Group 1, and 1500 IU hCG was administered intracavitary to 48 patients as Group 2. Results: Infertility causes, and characteristics of both groups were similar. Number of retrieved oocytes, Metaphase 2 (MII) oocytes and fertilization rates were similar in both groups. Implantation rate per embryo transferred was higher in the intracavitary group (p = 0.01). There was no significant difference for pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, livebirth rate and OHSS frequency between both groups. Twin pregnancy rate was significantly higher in the intracavitary group. Conclusions: Administration of 1500 IU hCG intracavitary at the time of OPU is associated with improved implantation rates when compared to subcutaneous hCG administration without a significant raise in OHSS occurrence. Prospective, randomized studies with bigger patient cohort are needed. © 2023 The Author(s).
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    Öğe
    Kovid-19 Pandemisinden Öğrenilen Dersler: Hayatı Tehdit Eden Bir Dönemde Gebelik Kaygı Düzeyi Artıyor
    (Alanya Alaaddin Keykubat Üniversitesi, 2023) Köle, Emre; Aksoy, Lale; Görgülü, Gökşen; Demir, Hakan; Köle, Merve Çakır; Aslan, Erdoğan
    Amaç: Bu çalışmada, COVID-19 enfeksiyonlu hamile kadınlardaki epidemiyolojik verilerle birlikte, pandemi sürecinde hastalığın oluşturduğu psikolojik etkileri ve pandemide artan anksiyetenin gebelik sonuçlarına etkilerini vurgulamayı amaçladık. Materyal ve Yöntemler: Bu çalışma,15 ila 49 yaşlarındaki 100 kadında gerçekleştirildi ve katılımcılar, Kadın Hastalıkları ve Doğum Polikliniği, Pandemi Polikliniği ve Gebelik Polikliniği'ne başvuranlardan seçildi. Kırk altı COVID-19 pozitif gebe kadın, kontrol grubu olarak negatif COVID-19 PCR testi olanlarla karşılaştırıldı. Katılımcılara bir anket ve Beck Anksiyete Envanteri uygulandı. Bulgular: Beck Anksiyete Envanteri kullanılarak yapılan bu çalışmada COVID-19 pozitif gebe grubunda anksiyete düzeylerinin COVID-19 negatif gebe grubuyla karşılaştırıldığında anlamlı derecede yüksek olduğunu gösterildi (p=0.001). Gruplar, pandemi sırasında gebe kalma ve doğum yapma açısından karşılaştırıldığında, "şiddetli anksiyete" nin COVID-19 negatif hamile grubunda anlamlı derecede arttığı bulundu (p=0.032). Sonuç: Beck Anksiyete Envanterine dayalı olarak, COVID-19 pozitif olanların negatif gruplarla karşılaştırıldığında gebelik sırasında anksiyete düzeylerini anlamlı derecede artırdığını tespit ettik.
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    The Effect of Prognostic Factors on Survival in Endometrioid Type Adenocancer
    (2023) Baştan, Merve; Kole, Merve Cakir; Aksoy, Lale; Köle, Emre; Çorakçı, Aydın
    Objective: The study aims to investigate the prognostic factors in uterine endometrioid adenocarcinoma that affect survival outcomes. Materials and Methods: This retrospective study includes 144 cases which underwent surgical treatment for uterine endometrioid adenocarcinoma. Demographic data and tumour characteristics were evaluated for lymph node metastasis. Stage I and grade 1-2 tumours were divided into lymphadenectomy and non-lymphadenectomy groups, and 5-year survival was assessed. Results: The presence of myometrial invasion of more than 1/2, adnexal metastasis and lymphovascular space invasion were found to be associated with lymph node metastasis (p=0.010 ve 0.019 ve 0.015). In our study, the 5-year survival rate was 87.4%. Survival rate was correlated with age, myometrial invasion, and tumour grade. The 5-year survival rates were 89.8% in lymphadenectomy group and 85.2% in non-lymphadenectomy group, and no statistically significant difference was observed (p=0.575). Conclusion: Myometrial invasion, grade and the age of diagnosis were detected as important prognostic factors of uterine endometrioid adenocarcinomas. We concluded that lymphadenectomy did not increase the survival rate of stage I grade 1-2 endometrioid tumours. Lymphadenectomy may not be performed in stage I grade 1-2 tumours; thus, the morbidities of lymphadenectomy can be avoided.
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    Vaginal micronized progesterone versus the levonorgestrel-releasing intrauterine system for treatment of non-atypical endometrial hyperplasia: A randomized controlled trial
    (Wiley, 2023) Gezer, Sener; Kole, Emre; Aksoy, Lale
    ObjectiveTo compare the efficiency of vaginal micronized progesterone (VMP) with the levonorgestrel-releasing intrauterine system (LNG-IUS) in patients with non-atypical endometrial hyperplasia. A validated Menorrhagia Impact Questionnaire (MIQ) was used to assess the quality of life before and after the procedure. MethodsIn this prospective trial, 144 women were randomly assigned to the VMP or LNG-IUS group. The primary endpoint was the regression rate of endometrial hyperplasia after 3 months of treatment. The protocol was approved by the institutional ethics committee and registered at (NCT03992937). ResultsIn all, 138 patients were analyzed. The regression rate was not significantly different between the groups (95.8% with LNG-IUS vs. 90.8% with VMP; P = 0.194). Differences between pre- and post-treatment MIQ scores were similar, except that better scores were obtained in the VMP group for the perception of the amount of blood loss (P = 0.035). ConclusionVMP is as effective as the LNG-IUS as a local treatment of endometrial hyperplasia without atypia. Trial registration.