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    Migraine and peripheral inflammation
    (Alanya Alaaddin Keykubat Üniversitesi, 2017) Yılmaz Avcı, Aynur; Akalin, Oktay
    Aim: Migraine is a commonheadache disorder that may be associated with inflammation and vasculardiseases. We evaluated C-reactive protein and the number of immune cells in theperipheral blood of young adult patients with migraine.Patients andMethods:This case–control study included 520 subjects: 260 patients with migraine(without aura, 169 patients; with aura, 91 patients) and 260 healthy controlsubjects (age range, 18–50 years). Participants had no known anemia, vascularrisk factors, or inflammatory diseases. We evaluated serum C-reactive proteinand complete blood count parameters in patients with migraine and controlsubjects.Results: C-reactive protein level,leukocyte, neutrophillymphocyte, platelet counts and mean platelet volumesignificantly differed in patients with migraine compared to controls(P<0.001). However, with the exception of C-reactive protein, theseparameters were similar in migraine with and without aura. Logistic regressionanalysis showed that migraine was significantly associated with C-reactiveprotein level (odds ratio [OR], 2.36; 95% confidence interval [CI],1.73–3.23; P<0.001), MPV (OR, 2.32; 95% CI, 1.78–3.0;P<0.001), and leukocyte count (OR, 1.61; 95% CI,1.32–1.94;). Conclusion: Increased levels ofperipheral inflammation may occur in patients with migraine and may be involvedin the pathogenesis of migraine.