Yazar "Şahin, Sevinç" seçeneğine göre listele

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    Öğe
    A Case of VEXAS Syndrome Presenting with Unexplained Headache
    (2025) Atas, Unal; Alhan, Nurcan; Beypınar, Dilek; Şahin, Sevinç; Keşkek, Şakir Özgür
    [Abstract Not Available]
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    Öğe
    Genitoüriner Tümörlerde Apelin/APJ ve Fibronektin Ekspresyonunun Değerlendirilmesi: Bir İmmünohistokimyasal Analiz
    (Rabia YILMAZ, 2023) Şahin, Sevinç; Avcı, Sema; Çiçekdağı, Işıl; Golal, Ezgi
    Amaç: Kanser, dünya genelindeki ölüm nedenleri arasında önde gelen bir durum olup, kanser araştırmaları ve yeni tedavi yöntemlerinin geliştirilmesi ciddi önem arz etmektedir. Mesane, endometrium ve prostat kanserleri, en yaygın kanser türleri arasında yer almaktadır. Bu çalışma, bu genitouriner tümörlerdeki endojen apelin/APJ reseptörü ve fibronektin ekspresyonunu ve dağılımını araştırmayı ve elde ettiği verileri benign dokularla karşılaştırarak literatüre katkı sunmayı amaçlamıştır. Gereç ve Yöntem: Endometrium, prostat ve mesaneye ait formalin ile fikse parafine gömülü benign ve malign dokularını içeren 44 vakaya immünohistokimyasal analiz uygulanmıştır. Bulgular: Endometrioid adenokarsinom, ürotelyal karsinom ve prostat adenokarsinomunda apelin, APJ ve fibronektin ekspresyonunda benign dokulara kıyasla önemli bir artış olduğu saptanmıştır. Ayrıca, bu tümörlerde bu moleküllerin ekspresyonu birbirleriyle doğrudan bir ilişki sergilemiştir. Bununla birlikte, prostat adenokarsinomunda ve endometrioid adenokarsinomunda tümör derecesi arttıkça, bu moleküllerin ekspresyonu azalmıştır. Sonuç: Bu çalışma, literatürde genitouriner tümörlerdeki endojen apelin/APJ reseptörü ve fibronektin ekspresyonunun ve dağılımının histolojik olarak benign karşılıklarıyla kıyaslandığı ilk çalışmadır. Elde edilen bulguların, apelin/APJ reseptörü ve fibronektinin tümorigenez ve kanser tedavilerindeki potansiyel rolleri açısından planlanacak daha ileri araştırmalar için bir temel oluşturacağı kanısındayız.
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    Öğe
    Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus
    (2023) Avcı, Sema; Şahin, Sevinç; Balcı, Cemre Nur
    Aim: This study aims to determine the role of IGF-1R in the etiology of sacrococcygeal pilonidal sinus and to evaluate the findings regarding its contribution to treatment. Material and Methods: The general structure of skin and connective tissue components in healthy and lesioned tissue sections of sacrococcygeal pilonidal sinus cases was evaluated by Masson trichrome staining. In addition, the expression of IGF-1R protein in healthy and pilonidal sinus tissue was determined by immunohistochemical staining. Results: It was observed that the epidermis of the pilonidal sinus was thinned compared to the healthy area, and the hair follicle structures and connective tissue components deteriorated. IGF-1R expression was significantly decreased in basal keratinocytes in sacrococcygeal pilonidal sinus tissues. Conclusion: It is thought that IGF-1R may be involved in the etiology of sacrococcygeal pilonidal sinus, and more data is needed in terms of its contribution to treatment.
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    Öğe
    Investigation of Toll-Like Receptor Family Expression in Glioblastoma: A Comparative Analysis of qPCR and Cell Culture
    (2023) Şahin, Sevinç; Sabah, Seda; Elmas, Levent; Hacisalihoglu, Uguray Payam; Yanık, Serdar
    Aim: Glioblastoma is the most frequent, and fatal brain cancer in adults. Toll-like receptors are cell surface receptors comprised of 10 receptors (Toll-like receptor 1?10) related to triggering innate immunity by recognizing pathogens. However, some studies suggested that the expression of Toll-like receptors might be related to cancer cell proliferation and progression in some tumors including glioblastoma with some contradictory results. Thus, we aimed to investigate all ten members of the Toll-like receptor expression profile in glioblastoma for the first time in the literature to contribute additional data to the literature. Patients and Methods: Quantitative real-time polymerase chain reaction was applied to formalin-fixed paraffin-embedded tissues of 25 glioblastoma patients, diagnosed between January and December 2018, to evaluate the mRNA expression of Toll-like receptors. Also, the expression of each Toll-like receptor was investigated by cell culture analysis using five different cell lines of human glioblastoma (T98G, U87-MG, U373, LN18, and A172). The results were compared statistically. Results: Toll-like receptor 1, Toll-like receptor 6, and Toll-like receptor 7 mRNA levels were significantly increased in the formalin-fixed paraffin-embedded tissues of the glioblastoma group (p<0.001, each) whereas the expression of Toll-like receptor 4 and Toll-like receptor 10 was downregulated compared to the control group (p=0.023, p<0.001, respectively), by quantitative real-time polymerase chain reaction analysis. Additionally, Toll-like receptor mRNA expression profiles differed among the cell lines. Conclusion: In our study, many Toll-like receptor members seemed to display different expression level in the glioblastoma microenvironment and affect it diversely. Further comprehensive studies are required to confirm the endogenous protein level of each Toll-like receptor in glioblastoma, to clarify their precise role in the pathogenesis and prognosis of glioblastoma, and to shed light on new target therapies.