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  • Küçük Resim
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    Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
    (2023) Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Tozlu, Özlem Özdemir; Arslan, Mehmet Enes; Hacımüftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Turkez, Hasan; Boren, Jan; Uhlen, Mathias; Mardinoğlu, Adil
    Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals. CMA promotes mitochondrial fatty acid uptake from the cytosol, facilitates fatty acid oxidation in the mitochondria, and alleviates oxidative stress. Methods Here, we designed a randomised, double-blinded, placebo-controlled phase-II clinical trial and studied the efect of CMA administration on the global metabolism of AD patients. One-dose CMA included 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%). AD patients received one dose of CMA or placebo daily during the frst 28 days and twice daily between day 28 and day 84. The primary endpoint was the diference in the cognitive function and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efcacy of the CMA in AD patients. Results We showed a signifcant decrease of AD Assessment Scale-cognitive subscale (ADAS-Cog) score on day 84 vs day 0 (P=0.00001, 29% improvement) in the CMA group. Moreover, there was a signifcant decline (P=0.0073) in ADAS-Cog scores (improvement of cognitive functions) in the CMA compared to the placebo group in patients with higher ADAS-Cog scores. Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis. Moreover, the plasma levels of
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    Öğe
    The Relationship Between Sociodemographic Factors, Severity of Depression and Anxiety, and Internet Addiction and Severity Among University Students in Alanya
    (2022) Uygur, Abdullah Burak; Celik, Selime; Güleken, Mehmet Diyaddin; Karakuş, Kadir; İdil, Ezgi
    Objective: This study was conducted to reveal the relationship between sociodemographic factors, severity of depression and anxiety, and internet addiction and severity among university students in Alanya. Methods: The sample consists of 537 students from different faculties who voluntarily accepted to participate in the research. The Sociodemographic Data Form, Beck Depression Inventory, Beck Anxiety Inventory, and Young Internet Addiction Scale were applied to the students. Results: Of the students, 74.5% (N=400) were defined as normal users, 25.3% (N=136) as mild–moderate internet addicts, and 0.2% (N=1) as severe internet addicts. Gender (P=.029), the purpose of internet usage being gaming (P=.012), information (P=.05), or pornography (P=.001), monthly income (P=.001), time spent on the internet (P=.001), tobacco use (P=.001), alcohol use (P=.001), number of siblings (P=.014), and history of psychiatric treatment (P=.049) were found to be sociodemographic factors associated with internet addiction. In addition, it was observed that students with internet addiction had higher depression (P=.001) and anxiety (P=.004) scores. Conclusion: The findings in the present study indicated that mild–moderate internet addiction is a relatively common problem among university students and carries a potential risk of developing into severe internet addiction. Simultaneous evaluation of university students for internet addiction when they attend psychiatric outpatient clinics for complaints of depression, anxiety, tobacco and alcohol addiction will make a significant contribution to the fight against internet addiction.