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Öğe Açılı Yerleştirilen Dental İmplantların Klinik Başarısı: Bir Uzun Süreli Gözlem Çalışması(2024) Ocak, Hakan; Çolpak, Halis Ali; Çolpak, Emine DilaraAmaç: Çenelerdeki çeşitli anatomik ve fizyolojik sınırlandır- malar sebebiyle diş eksikliklerinin tedavisinde, optimum bo- yutlarda dental implant yerleştirilmesi bazı durumlarda ek cerrahi işlemler gerçekleştirilmeden mümkün olmamaktadır. Alternatif tedavi seçeneği olan kısa implantların da klinik ba- şarılarının tartışmalı olması sebebiyle gününümüzde dental implantların açılı olarak yerleştirildiği tedavi seçenekleri gittik- çe popüler hale gelmektedir. Çalışmamızın amacı hastaların çenelerine açılı olarak yerleştirilen dental implantların klinik ve radyolojik özelliklerini belirlemek ve uzun dönem takipleri sonucunda klinik sağ kalımlarını değerlendirmektir. Gereç ve Yöntem: Hastalara açılı olarak yerleştirilen implant- ların yerleştirme tork değeri, ISQ değeri, yerleştirildiği bölge- nin varyasyonları ve eğim açıları kayıt edildi. Ortalama 21,7 ± 10,8 ay takipleri sonucu implant kayıpları ve implantın etrafın- daki boyun rezorbsiyonları tanımlayıcı ve demografik istatis- tiksel yöntemlerle değerlendirildi. Bulgular: Araştırmaya dahil edilen bireylerin 33’ü (%60) erkek ve 22’si (%40) ise kadın idi. İmplantların 17’si üst tuber, 24’ü üst premolar kanin ve 14’ü ise alt premolar kanin bölgesine yerleştirildi Yerleştirilen implantların; eğim açısı ortalama 47 ± 9,8 derece, implantın çapı ortalama 4,1 ± 0,4 mm, implant boyu ortalama 11,9 ± 1,7 mm olarak belirlendi. Bir vakada implant kaybı yaşanırken implantların ağızda kalma oranı %99 olarak belirlendi. Sonuç: Dişsiz çenelerin kısa sürede protetik rehabilitasyonu için implantların açılı olarak yerleştirildiği tedavi protokolü sayesinde, özellikle optimum boyutlarda dental implant yer- leştirilemeyen hastalarda öngörülebilir sonuçlarla başarılı bir tedavi olarak uygulanabilir.Öğe Analysis of traumatic bone cyst of the jaws: A retrospective study(2019) Demirbaş, Ahmet Emin; Çolpak, Halis Ali; Kütük, Nükhet; Gönen, Zeynep Burçin; Alkan, AlperObjective: Traumatic bone cysts (TBC) are rare in the jaws, and may be characterized by the presence of a cavity in bone with no epithelial lining. Clinically, TBC is asymptomatic and often discovered incidentally on routine radiographic examination. The purpose of this study was to describe the clinical, surgical, and radiographic features of TBCs.Materials and Methods: Records of patients with cystic lesions, who were treated in our clinic between 2006 and 2016, were examined. Twenty-two TBCs were detected among all odontogenic/nonodontogenic cysts. Clinical, radiographical, histopathological features of TBCs and follow-up information of the patients were analyzed retrospectively.Results: The mean age of the patients was 18.5. The incidence of the TBC was found 1.05%. All lesions were found in the mandible, and were diagnosed incidentally during routine dental examinations except two cases have pain. Most cases showed a cavity without an epithelial lining, and were treated with curettage. No complications occurred during follow up period.Conclusion: TBCs are rare seen in the jaws, and the mandible is generally affected site. Bone healing may be accomplished successfully with the curettage of the cyst cavity.Öğe Are preoperative hematologic parameters predictive of intraoperative bleeding in orthognathic surgery?(2021) Canpolat, Dilek Günay; Çolpak, Halis Ali; Kütük, Nükhet; Alkan, AlperAim: Orthognathic surgery is performed to correct dentofacial abnormalities and is generally known as a safe procedure with minimal bleeding. The purpose of this study was to evaluate whether the preoperative hematological parameters help predict intraoperative bleeding in orthognathic surgery. Material and Methods: This retrospective study was performed with patients who underwent orthognathic surgery. Patients records were evaluated in terms of the demographics (gender, age, weight), duration of the surgery, amount of intraoperative bleeding, and the preoperatively routine complete blood count (CBC) parameters, especially PLT, MPV, MPV/PLT ratio, coagulation tests (PT, a PTT, INR) and NLR were recorded from patient files. Results: The study included 101 patients with a mean age of 21.7 +/- 4.8 years. The female to mate ratio was 1.1 (52/49). The median duration of the operation was 270 minutes, ranging from 155 to 420 minutes. The amount of blood loss ranged from 90 to 820 ml in all subjects, with a median of 230 ml. The preoperative median hemoglobin value was 14.4 g/dL PT, INR, aPTT, and weight were not independent predictors for the amount of bleeding. However, the duration of the surgery was an independent predictor for the amount of bleeding (p<0.001). There was no correlation between the MPV/PLT ratio (r=0.003, p=0.972) and the neutrophil-to-lymphocyte ratio (NLR) (r--0.008, p=0.935) with the amount of bleeding (ml). Discussion: Improving possible objective markers to predict intraoperative bleeding amounts is important for avoiding and managing the intraoperative bleeding complications for the surgery team in maxillofacial surgery. The results of this study demonstrated no correlation between preoperative hematologic normal ranged parameters such as PLT, MPV, MPV/PLT, NLR, PT, PTT, INR, and intraoperative bleeding in orthognathic surgery. Thus, caution in the preparation of patients and standardized preoperative procedures are essential to avoid undesirable intraoperative bleeding in orthognathic surgery.Öğe Comparison of the effectiveness of rapamycin and gabapentin treatment in rats with induced sciatic nerve injury(2022) Canpolat, Mehmet; Çolpak, Halis Ali; Günay Canpolat, Dilek; Önder, Gözde Özge; Yetkin, Mehmet FatihObjective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model. Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI). Medical treatment was administered intraperitoneally for 30 days after the induction of SN injury. Results: Significant differences (p<0.001 for all) were found in comparisons between the groups in terms of axon diameter, axon number, and neurofilament (NF) and S100 immunointensity. Among the treatment groups, the highest mean axon diameter value, close to that of the Control group, was seen in the RAPA-L group. In terms of axon number, the value closest to that of the Control group was measured in the GBP group. The NF and S100 immunodensity in the RAPA-L group was similar to that of the GBP group. The S100 immunodensity in the RAPA-L group was closest to that of the Control group. The highest conduction velocity and distal latency values were recorded in the RAPA-L group. Conclusion: The histological and electrophysiological findings observed in this study suggest that RAPA-L treatment is a promising alternative to GBP.Öğe Comparison of the effects of ozone therapy and photobiomodulation on sciatic nerve injury in rat(2021) Canpolat, Dilek Günay; Yücesoy, Türker; Çolpak, Halis Ali; Çilingir-Kaya, Özlem Tuğçe; Kolbaşı, Bircan; Saraymen, Recep; Karatürk, Habip; Kütük, Nükhet; Canpolat, MehmetAim: Studies on drugs or alternative therapies are still the main treatment options for PNI. In this study, we aimed to research the effects of PBM and OT on nerve repair in a rat sciatic injury model. Material and Methods: 29 Wistar albino rats were divided into four groups: control (n = 2), sham (n = 9), OT (n = 9) and PBM (n = 9). After 30 days of surgery and treatments, tissue specimens and blood samples were taken for histological and biochemical processing. Histological evaluations were performed at light and electron microscopy levels. Myelin basic protein (MBP) and S100 from the rat serum were analysed also. Results: The OT and PBM groups had a significant increase in regeneration of the sciatic nerve in light microscopic evaluation. In the PBM and OT groups, Schwann cells (SC) around the axons and also axons with a thin myelin sheath were seen, regarded as signs of the myelination process in transmission electron microscopy (TEM) examinations. Discussion: OT and PBM both resulted in a good healing pattern for sciatic nerve injury in the rat model. Therefore, OT and PBM are considered to be simple and reliable alternative treatment methods for PNI.Öğe Effects of bisphosphonate treatment on mandibular condyle tissues of temporomandibular joint: A stereological study(Elsevier, 2019) Gönen, Zeynep Burçin; Çolpak, Halis Ali; Önger, Mehmet EminIntroduction: Although the adverse effects due to the use of bisphosphonates, such as bisphosphonate-induced osteonecrosis of the jaw, are reported previously, whether adverse events of the temporomandibular joint related with bisphosphonate treatment have been still unclear. Therefore, the aim of this study is to evaluate the effects of BP treatment on the condylar tissues of the temporomandibular joint due to fibrous cartilage, hyaline cartilage and bone-specific differences in rat animal models. Material and method: A total of 12 adult Wistar-Albino rats, weighing from 250 to 300 g were included to the study. The animals were randomly divided into two groups. 0.1 mg/kg Zoledronic Acid were administrated to the animals intraperitoneally in the experimental bisphosphonate group for 60 days. Rest of the animals left as healthy control. All the animals were sacrificed at the end of 60 days. Two condyles were obtained from each animal and total 12 condyles were included to histological analysis in each group. The fibrous cartilage volume, hyaline cartilage volume and bone volume of the condyle were calculated using Cavalieri method. Statistical analysis was performed with Turcosa software. Results: There is a statistically significant difference of fibrous cartilage (P = 0.003) and bone volume between groups (P = 0.002). However, mean hyaline cartilage volume does not statistically differ between groups (P = 0.47). Bone volume and firbrous cartilage volume were increased in bisphosphonate group than control. Conclusion: According to our study results Zoledronic Acid treatment did not affect the hyaline cartilage volume however fibrocartilage volume and bone volume were increased when the animals received ZA intraperitoneally for 60 days. (C) 2019 Published by Elsevier Masson SAS.Öğe Is the jet injection effective for teeth extraction?(Elsevier, 2020) Ocak, H.; Akkoyun, Emine Fulya; Çolpak, Halis Ali; Demetoğlu, Umut; Yücesoy, Türker; Kılıç, Ertuğrul; Alkan, ArzuPain control is achieved typically by means of injection of local anesthesia for invasive procedures to carry out procedures with as little pain or discomfort as possible. Although this method is highly effective, patients often fear more from the sight of a needle during administration of local anesthetic than from the treatment. Therefore, needleless local anesthesia with a jet injection device has been proposed. With the INJEX (R), anesthetic solution is forced under high pressure into the oral mucosa, leading to mechanical infiltration of the compound through the mucosa. With this study, we aimed to show the effectiveness of the needleless injection for infiltrative anesthesia and compare the acceptance and efficacy between jet injection with INJEX and local infiltration anesthesia. 28 adult patients admitted to our department for tooth extraction were included in the study. Two symmetrical teeth in the same jaw were extracted from each of the patients. Jet injection with the INJEX (R) was performed on one side and classical (needle) infiltration anesthesia on the other side with 0.3 cc Ultracain DS forte (Sanofi Aventis, Istanbul, Turkiye) on buccal and lingual aspects and 0.1 cc on palatal aspects of the teeth. The difference between pain and discomfort scores experienced during tooth extraction was statistically significant (P = 0.026). Accordingly, the pain or discomfort score of the INJEX (R) method during tooth extraction was significantly higher. Jet injection with the INJEX (R) was not found to be effective for local infiltrative anesthesia especially teeth extractions. It may be more acceptable when using for previously classical local infiltration anesthesia by patients. The main problem with jet injection was the "pop" sound when the INJEX (R) device was pressed, and also inadequate suppyling the anesthesia. (C) 2019 Elsevier Masson SAS. All rights reserved.Öğe Which dental implant surface is more effective in osteointegration: RBM surface versus SLA surface(2021) Demetoğlu, Umut; Ocak, Hakan; Songür, Timur; Çolpak, Halis AliAim: The surface characteristics of an implant direct the wound healing and are an important factor for osteointegration. There are very few studies evaluating or comparing the clinical success of osteointegration of sandblasting with larger grit and acid etching (SLA) and rough surface as required by grit blasting (RBM) surfaces, which are important surface factors in selecting an implant. The aim of this study was to evaluate the osteointegration success in a total of 4793 implants in 2005 patients in SLA and RBM surface cylindrical implants of the same trademark and type. Material and Methods: A total of 4793 implants and 2005 patients composed of 943 females and 1062 males were included in this study. Regions of implant applications were grouped into anterior and posterior parts of the mandible and anterior and posterior parts of the maxilla and evaluated with success rates. Results: Among the implants, 1877 were RBM surface and the remaining 2675 had SLA surface. Seventy-four implants among the 1877 RBM surface implants failed (%96.06). The success rates were 94.75 % and 97.22%, maxilla and mandible, respectively. Among the 2675 SLA surface implants, 93 failed (%96.53). The success rates were 95.29% and 97.11% in maxilla and mandible, respectively. Discussion: Recently, the studies have demonstrated increased bone and implant contact areas and a high degree of osteoconductive property when applied to surfaces in histological studies. In the presented study, RBM and SLA surface implants with the same trademark and same design were clinically compared, and no significant difference was found between them in terms of osteointegration success.
