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Öğe Does cerebrospinal fluid IL-17F distinguish normal pressure hydrocephalus from dementia?(2024) Karabörk, Şeyda; Çelik, Hümeyra; Turkoglu, Sule AydinAim: The neurological disorder known as normal pressure hydrocephalus (NPH), which has an unknown cause, may be treatable, and is defined by a clinical triad of symptoms. A phenomenon known as dementia refers to a decline in cognitive performance that goes beyond what may be anticipated from the typical effects of biological aging. The symptomatic similarity between these two diseases causes problems in diagnosis. The objective of our study was to compare the concentrations of IL-17A, IL-17F, IL-34, and CXCL13 in the cerebrospinal fluid (CSF) of patients with NPH and dementia for an informative laboratory diagnosis. Methods: The study included NPH and dementia cases (n=7, n=5, respectively) taken from the patients’s CSF sample by lumbar puncture (LP). The levels of IL-17A, IL-17F, IL-34, and CXCL13 were measured in the CSF of patients' with NPH and dementia by enzyme-linked assay (ELISA) and compared between the two different groups. Results: There was no difference in age between the NPH and dementia groups (p=0.5). There was no statistically significant difference was found in IL-17A (p=0.7), IL-34 (p=0.9), and CXCL13 (p=0.2) in the inflammatory marker analysis in the CSF. The groups had a statistically significant difference in IL-17F (p=0.04). Conclusion: IL-17F can be an important laboratory marker used in the differential diagnosis of NPH and dementia.Öğe Gestasyonel Diyabetes Mellitus Tanısında Amilin ve Amilinin Olumsuz Obstetrik ve Yenidoğan Sonuçları ile İlişkisi(T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi, 2025) Mungan, Sanem; Çelen, Şevki; Tokmak, Aytekin; Çelik, HümeyraAmaç: Çalışmanın amacı, 24-28. haftalar arasında oral glukoz tolerans testi (OGTT) için başvuran gebelerde serum amilin düzeylerini ölçmek, gestasyonel diabetes mellitus (GDM) tanısı almış ve almamış gebelerde amilinin tanısal kullanımını karşılaştırmak ve amilin değerleri ile obstetrik-neonatal sonuçlar arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntemler: Çalışmaya OGTT için antenatal polikliniğe başvuran 430 gebe arasından 86 hasta dahil edildi. 50 gr OGTT sonuçları normal sınırlarda olan gebelerden 43'ü; 50 gr OGTT'si 140 mg/dl'nin üzerinde olduğu için 100 gr OGTT testi yapılan ve 2 değeri bozuk olduğu için GDM tanısı konulan 43 gebe çalışma grubu olarak belirlendi. Serum amilin düzeyleri, kontrol ve çalışma grupları vücut kitle indeksine (VKİ) göre eşleştirilerek değerlendirildi. Sonuçlar: Çalışmada serum amilin düzeyleri GDM grubunda 73,7, kontrol grubunda ise 76,1 olarak bulundu ve gruplar arasında anlamlı farklılık yoktu (p>0,05). Amilin düzeyleri GDM grubunda yaş, BKİ, gravida, parite ile negatif, kazanılan kilo ve gebelik haftası ile pozitif korelasyon gösterdi. Gruplar arasında obstetrik (doğum haftası, doğum ağırlığı, doğum şekli, doğum travması) ve yenidoğan (NEDCU ihtiyacı) sonuçları açısından istatistiksel olarak anlamlı bir fark yoktu (p>0,05). Sonuç: OGTT'den önce ölçülen serum amilin konsantrasyonları GDM tanısı için öngörücü bir değere sahip değildir ve serum amilin düzeyleri olumsuz obstetrik ve neonatal sonuçları öngörmez.Öğe Lymphocyte-to-Monocyte Ratio is a Good Marker of Adhesive Capsulitis in Rotator Cuff Tears(2023) Celık, Ilhan; Çelik, Hümeyra; Ayanoğlu, Tacettin; Arıkan, Emre; Kayıs, Seyit AliPurpose: The aim of the study is to evaluate the prediction of adhe - sive capsulitis in the preoperative period of rotator cuff tear (RCT) by neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), neutro- phil-monocyte (NMR), lymphocyte-monocyte (LMR) ratios. Methods: This study was designed as a retrospective case-control study. After ethical approval, preoperative hemogram and biochemis- try data of 128 patients who were operated on for RCT were collect- ed from the archive of hospitale. Among the patients who underwent arthroscopy due to RCT, those with signs of adhesive capsulitis in the intraoperative period were included in the RCT+Adhesive capsulitis group. Age, blood glucose, CRP, sedimentation, white blood cell, neu- trophil, monocytes, lymphocytes, platelets, fasting blood glucose, he- moglobin and hematocrit values, and NLR, PLR, NMR, and LMR ratios were compared between healthy control and RCT+Adhesive capsulitis. Logistic regression analysis of the ratios was also performed. Results: A total of 64 healthy RCT (group 1) and 64 patients with RCT+Adhesive capsulitis (group 2) were included in the study. Fasting blood glucose, lymphocyte, CRP values, and NMR and LMR were found to be higher in patients with adhesive capsulitis (p<0.05); and mono - cyte, NLR and PLR were found to be lower in group 2 compared to group 1 (p<0.05). According to ROC analysis, it was revealed that LMR was the best predictor of adhesive capsulitis in RCT. Conclusion: It has been demonstrated that the inflammation rate LMR obtained from the hemogram, which is an easy, low-cost, and repro- ducible method, is a variable that predicts adhesive capsulitis in RCT.Öğe Protective Effects of Aronia melanocarpa Extract against Cyclophosphamide-Induced Delayed Toxicity on the Bladder(2025) Çelik, Hümeyra; Karabörk, Şeyda; Saylan, Aslihan; Çetınkaya, AyhanAim: Aronia melanocarpa is a red-purple medicinal fruit known for its therapeutic properties in the urinary system by anti-inflammatory effects with high antioxidant content. The aim of the study is to show the supportive effect of Aronia melanocarpa extract delayed toxicity on the bladder induced by cyclophosphamide (CYC) that an antineoplastic agent. Material and Methods: In the study three groups were constituted control (n=7), CYC(urotoxicity group, n=7) and CYC+ARONIA(treatment group, n=7). 100 mg/kg CYC intraperitoneally were given to CYC and CYC+ARONIA groups and waited for 4 weeks to be created delayed toxicity. At the end of the 4 weeks, 200 mg/kg Aronia melanocarpa was administered 15 times by oral gavage every other different day to CYC+ARONIA group (1 month in total). Sacrification was performed and after serum and urine samples were taken, the bladder was released from the sphincter region with curved-tipped forceps. Bladder tissues were investigated histologically. P38 mitogen activated preotein kinase (P38 MAPK), total antioxidant (TAS) and oxidant (TOS) status were evaluated in serum and urine samples. Results: In histology, histological damage in the bladder continued in the CYC group, while Aronia melanocarpa treatment caused healing in the bladder tissue in the CYC+ARONIA group. No difference was found between the groups in terms of P38 MAPK, TAS and TOS in serum and urine samples. Conclusion: According to the experimental results, the fact that Aronia melanocarpa extract improves the histological damage caused by CYC in the delayed period, and the serum and urine findings were the same as the controls, brought up the therapeutic effect of Aronia melanocarpa in urotoxicity.Öğe The therapeutic role of Aronia melanocarpa on cyclophosphamide-induced premature ovarian failure(2024) Çelik, Hümeyra; Kara, Sinem; Bozat, Bihter Gökçe; Uluc, Firdevs; Çetınkaya, Ayhan; Fırat, TülinThe purpose of the study was to evaluate the effects of Aronia melanocarpa (A. melanocarpa) extract on ovarian cell apoptosis, vascularization, and follicle reserve in the premature ovarian failure (POF) induced by cyclophosphamide (CYC). After creating a premature ovarian failure model with 100 mg/kg CYC, A. melanocarpa was given to Wistar albino female rats by gavage 15 times every other day (200 mg/kg).Vaginal smears were taken to evaluate the estrus cycles before, during and at the end of the experiment. Histological ovarian follicle count was performed by examining the ovaries with Hematoxylin&Eosin staining. Immunohistochemical evaluation of apoptosis markers of caspase-3 (cas-3), caspase-9 (cas-9) and vascular endothelial growth factor (VEGF) was performed. A. melanocarpa reregulated the estrus cycles in a similar way to the controls by reducing cas-3 and cas-9 in ovarian cells and increasing the number of ovarian cells. While CYC disrupted ovarian vascularization, A. melanocarpa contributed to ovarian reserve by increasing VEGF immunopositivity. In chemotherapy-induced POF, A. melanocarpa extract increases ovarian reserve by providing vascularization, decreasing apoptosis and providing cycle control in female rats.
