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    Öğe
    Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
    (Frontiers Media Sa, 2019) Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Kılıç, Ertuğrul
    Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which the rTMS exert beneficial effects in cellular and molecular aspect are largely unknown. To elucidate the effects of high- and low-frequency rTMS in the acute-ischemic brain, we examined how rTMS influences injury development, cerebral blood flow (CBF), DNA fragmentation, neuronal survival, pro- and anti-apoptotic protein activations after 30 and 90 min of focal cerebral ischemia. In addition, inflammation, angiogenesis, growth factors and axonal outgrowth related gene expressions, were analyzed. Furthermore, we have investigated the effects of rTMS on post-acute ischemic brain, particularly on spontaneous locomotor activity, perilesional tissue remodeling, axonal sprouting of corticobulbar tracts, glial scar formation and cell proliferation, in which rTMS was applied starting 3 days after the stroke onset for 28 days. In the high-frequency rTMS received animals reduced DNA fragmentation, infarct volume and improved CBF were observed, which were associated with increased Bcl-xL activity and reduced Bax, caspase-1, and caspase-3 activations. Moreover, increased angiogenesis, growth factors; and reduced inflammation and axonal sprouting related gene expressions were observed. These results correlated with reduced microglial activation, neuronal degeneration, glial scar formation and improved functional recovery, tissue remodeling, contralesional pyramidal tract plasticity and neurogenesis in the subacute rTMS treated animals. Overall, we propose that high-frequency rTMS in stroke patients can be used to promote functional recovery by inducing the endogenous repair and recovery mechanisms of the brain.
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    Öğe
    Hindistan Cevizi Yağının Travmatik Beyin Hasarı Olan Farelerde Nöroprotektif Etkisi
    (Kahramanmaras Sutcu Imam University, 2021) Çankaya, Şeyda; Günal, Mehmet Yalçın; Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Özdemir, Ekrem Musa; Saatci, Özlem; Çankaya, Barış
    Amaç: Bu çalışmada hindistan cevizi yağının travmatik beyin hasarı olan farelerde olası nöroprotektif etkisini değerlendirmeyi amaçladık. Materyal ve Metod: Fareler rastgele iki gruba ayrıldı (grup başına n = 5); diğer bir deyişle, kontrol ve Hindistan cevizi yağı grubu; sırasıyla soğuk beyin hasarından önce bir hafta boyunca 250 ul salin ve her bir os hindistancevizi yağı başına 10 mg / kg vücut ağırlığına göre belirlendi. Beyindeki enfarktüs ve ödem hacmi yaralanmadan 24 saat sonra sekizinci günde iki grupta Kresil Moru ile ölçüldü. Bulgular: Verilerimiz, hindistancevizi yağı uygulamasından sonra enfarktüs ve ödem hacimlerinde istatistiksel olarak anlamlı bir düşüş olduğunu gösterdi. Sonuç: Bulgularımız, hindistancevizi yağının farelerde travmatik beyin hasarı sonrası hasarlı nöronlar üzerinde potansiyel bir nöroprotektif etkiye sahip olduğunu desteklemiştir.
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    Öğe
    The effects of topical liposomal resveratrol on incisional and excisional wound healing process
    (2019) Günal, Mehmet Yalçın; Ayla, Şule; Bedri, Nejda; Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Aslan, İsmail; Kılıç, Ülkan
    Background and Design: The objective of this study was to investigate the wound healing activity of different concentrations of liposomal trans-resveratrol formulations on incisional and excisional wounds in rats. Materials and Methods: The wound healing effect was tested by an excisional and incisional wound model. Wound closure was measured for 12 days. On the 12th day of the study, maximal load, maximum stress, stress, and % of elongation values were evaluated in the incisional wound. In addition, angiogenesis, granulation tissue thickness, epidermal and dermal regeneration values, and macroscopic photographic analyses were evaluated in the excisional wound. Results: When the wound tissue surface healing rates were evaluated, similar effects were observed at the end of the 10th and 12th days between the 5% Res group and the commercial product containing 1% Centella asiatica extract used as the reference molecule. Histological evaluation showed that 1% Res and 5% Res groups induced significant wound healing activity compared to the control group. Furthermore, 1% Res and 5% Res groups increased wound healing rates by promoting granulation tissue, epidermal, and dermal regeneration as well as angiogenesis. Conclusion: Liposomal formulations containing 1% and 5% resveratrol were found to have positive effects on the healing process, both on excisional and incisional wound tissues.