Çakır, Özlem ÖzerFındık, Sıddıka2021-02-192021-02-1920181687-61211687-630Xhttps://doi.org/10.1155/2018/9829208https://hdl.handle.net/20.500.12868/359FINDIK, SIDDIKA/0000-0002-3364-7498Aim. We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice. Methods. A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment. Results. Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P < 0 001, P < 0 001, P < 0 001, P < 0 001, and P = 0 048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P < 0 001, P < 0 001, P < 0 001, P = 0 030, and P < 0 001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P = 0 008, P = 0 014, and P < 0 001, respectively); and mean congestion and hydropic degeneration scores in the liver (P = 0 029 and P = 0 002, respectively). Conclusion. Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis.eninfo:eu-repo/semantics/openAccessDiclofenac sodium treatment ameliorates extrapancreatic organ injuries in a murine model of acute pancreatitis induced by caeruleinArticle10.1155/2018/9829208201830515205Q2WOS:000449871200001N/A