Avnioglu, SedaSahin, CanerCankaya, SeydaOzen, OzkanDikici, RumeysaYilmaz, HalilVelioglu, Halil Aziz2026-01-242026-01-2420230022-39561879-1379https://doi.org/10.1016/j.jpsychires.2023.01.015https://hdl.handle.net/20.500.12868/5752Purpose: Neuroimaging studies have shown that anosmia is accompanied by a decreased olfactory bulb volume, yet little is known about alterations in cerebral and cerebellar lobule volumes. The purpose of this study was to investigate structural brain alterations in anosmic patients.Methods: Sixteen anosmic patients (mean age 42.62 +/- 16.57 years; 6 women and 10 men) and 16 healthy controls (mean age 43.37 +/- 18.98 years; 9 women and 7 men) were included in this retrospective study. All subjects who underwent magnetic resonance imaging scans were analyzed using VolBrain and voxel-based morphometry after olfactory testing.Results: Despite being statistically insignificant, analysis using VBM revealed greater gray matter (GM) and white matter in the anosmia group compared to the healthy subjects. However, decreased GM (p < 0.001) and increased cerebellar (p = 0.046) volumes were observed in the anosmic patients.Conclusions: The study revealed structural brain alterations in specific areas beyond the olfactory bulb. Our re-sults indicate that the cerebellum may play an exceptional role in the olfactory process and that this will be worth evaluating with further dynamic neuroimaging studies.eninfo:eu-repo/semantics/closedAccessAnosmiaBrain volumeVBMVolBrainMRIArticle10.1016/j.jpsychires.2023.01.0151608692367915322-s2.0-85148768234Q1WOS:000944371800001Q1