Çinar, EsatYüce, BernaAslan, Fatih2026-01-242026-01-2420240886-3350https://doi.org/10.1097/j.jcrs.0000000000001511https://hdl.handle.net/20.500.12868/4546Purpose:To assess corneal sensitivity and the ocular surface in patients undergoing primary femtosecond laser in situ keratomileusis (FS-LASIK) and those undergoing FS-LASIK retreatment under the same flap due to residual refractive error.Setting:Ekol Eye Hospital, Izmir, Turkey.Design:Prospective case series.Methods:19 patients with previous FS-LASIK who had myopic and astigmatic refractive error were included in the study group, and 19 age-matched and sex-matched patients undergoing FS-LASIK for the first time as the control group. Corneal sensitivity, Schirmer test, tear film break-up time (TBUT), Oxford grading scheme for ocular surface staining, and Ocular Surface Disease Index (OSDI) were measured preoperatively and at postoperative 1 week and 1, 3, and 6 months.Results:The mean refractive correction in the study and control groups, respectively, was 2.18 ± 0.78 diopters (D) (range: 1.00 to 3.50) and 2.76 ± 1.20 D (range: 1.00 to 4.50; P =.07). Corneal esthesiometry results in the study and control groups, respectively, were 6.10 ± 12.55 vs 9.90 ± 11.50 mm at 1 week (P =.001), 41.95 ± 6.98 vs 45.09 ± 5.88 mm at 1 month (P =.004), 56.09 ± 3.37 vs 56.19 ± 2.52 mm at 3 months (P =.8), and 58.60 ± 2.01 vs 58.80 ± 1.39 mm at 6 months (P =.5). Significant difference between the 2 groups in Schirmer test score that disappeared at postoperative 3 months and in TBUT and ocular surface staining that disappeared at 6 months, whereas the statistically significant difference in OSDI score persisted at 6 months (P =.03) was detected.Conclusions:Corneal surface sensitivity and ocular surface health are more impaired in patients undergoing FS-LASIK retreatment due to residual refractive error. ©2024 Published by Wolters Kluwer on behalf of ASCRS and ESCRS. Unauthorized reproduction of this article is prohibited.eninfo:eu-repo/semantics/closedAccessfluorescein sodiumfluorometholonepovidone iodineproxymetacainetobramycinadultArticleastigmatismclinical articlecontrolled studycorneal sensitivitycorneal thicknessdenervationfemalehumankeratometrylaser in situ keratomileusismalemyopiaocular surface diseaseOcular Surface Disease Indexpostoperative periodpreoperative periodprospective studyrefraction errorretreatmentretrospective studySchirmer testsurgical techniquetear break-up timetopical anesthesiavisual system functionvisual system parameterscorneadrug therapyexcimer lasereye refractionlacrimal fluidmiddle agedpathophysiologyphysiologyproceduresreoperationsurgeryvisual acuityyoung adultAdultAstigmatismCorneaFemaleHumansKeratomileusis, Laser In SituLasers, ExcimerMaleMiddle AgedMyopiaProspective StudiesRefraction, OcularReoperationTearsVisual AcuityYoung AdultArticle10.1097/j.jcrs.0000000000001511501111011108389404692-s2.0-85207663688Q1