Ozgul, MustafaAydogan, Eyup2026-01-242026-01-2420251386-02911875-8622https://doi.org/10.1177/13860291251352350https://hdl.handle.net/20.500.12868/5140Background: Sacubitril is an important and effective agent for cardiovascular remodeling. This study aims to evaluate its proangiogenic effects in an experimental model. Methods: The chorioallantoic membrane (CAM) model was created for the investigation of the proangiogenic potential of sacubitril with different therapeutic doses (10(-7) M, 10(-6) M, 10(-5) M) and compared with drug-free pellet group (sham) and normal morphology (control) of chick embryo development in drug-free chick embryos. The developing embryo's vascularity and the pellets' effect were evaluated under a stereoscopic microscope. The density of vascular shoots and newly formed vascular nodules were not recorded. Results: There was no significant difference between the control and drug-free pellet groups (12.4 +/- 2.8 vs. 14.1 +/- 1.3 junctions per ROI, p = 0.48). The incremental angiogenic properties were detected in drug groups as follows: 15.3 +/- 3.8 per ROI in Group I (10(-7) M concentration); 21.6 +/- 5.4 per ROI in Group II (10(-6) M concentration); 22.9 +/- 8.1 per ROI in Group III (10(-5) M concentration) (p < 0.001). Conclusion: Our findings support that sacubitril provokes angiogenesis in a dose-dependent manner. Investigating these properties can be useful for understanding further effects of this agent in other cardiovascular diseases. Therapeutic angiogenesis is important for ameliorating the results.eninfo:eu-repo/semantics/closedAccessSacubitrilangiogenesisCAM modelremodelingArticle10.1177/13860291251352350903116121406249862-s2.0-105014130065Q2WOS:001524180600001N/A