Erdogan, Ayse2026-01-242026-01-2420242458-9179https://search.trdizin.gov.tr/tr/yayin/detay/1294599https://doi.org/10.30569/adiyamansaglik.1522904https://hdl.handle.net/20.500.12868/3797Aim: The aim of this study was to reveal whether carfilzomib, proteasome inhibitor, and carvacrol, a natural monoterpenic phenol, causes cytotoxic and apoptotic effects and oxidative stress on A-549 cells. Materials and Methods: Lactate dehydrogenase (LDH) activity test was used. Changes in caspase 3 and glutathione peroxidase enzyme activities in cells were determined. Results: It was determined that carfilzomib alone and together with carvacrol caused a raise in the activities of lactate dehydrogenase (LDH), glutathione peroxidase and apoptotic enzyme, caspase-3 activity, compared to the control. Conclusion: Our study showing that carfilzomib alone and together with carvacrol gave different responses may be guiding in determining new strategies to be applied in lung cancer treatment.eninfo:eu-repo/semantics/openAccessLung cancerCarfilzomibCarvacrolApoptotic effectArticle10.30569/adiyamansaglik.15229041031891991294599