Kurt, GızemÇelik, DenizYıldız, MuratÖzdağ, Özlem2026-01-242026-01-2420232717-8994https://search.trdizin.gov.tr/tr/yayin/detay/1161605https://doi.org/10.53446/actamednicomedia.1143661https://hdl.handle.net/20.500.12868/3786Objective: Several studies have shown low mean corpuscular hemoglobin concentration (MCHC) associations with mortality and poor clinical course in conditions associated with chronic inflammation, such as cardiac failure and COPD. Thus, this study aimed to determine the link between MCHC and readmission mortality in a large patient population with a minimum of 1 year of follow-up. Methods: We recorded clinical data at admission, laboratory data, the number of admissions to the emergency room due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) following the discharge of the last patient recruited, the number of admissions to the pulmonology unit, and the number of intensive care unit admissions between 2018 and 2019. The follow-up duration ranged between 12 and 36 months. Results: A total of 339 patients were included. Based on a ROC analysis, the cut-off value for MCHC was 32.35 g/dl. Comparison of clinical data according to this cut-off value showed an increase in the incidence of pneumonia during admission, hypercapnic respiratory failure, need for noninvasive mechanical ventilation (NIV), and the number of intensive care unit admissions within one year, as well as reduced survival in nonanemic subjects with MCHC ? 32.35 g/dL. In multivariate cox-regression analysis, MCHC was not an independent predictor of mortality risk. Conclusion: We recommend careful monitoring and assessing comorbidities in acute exacerbation of COPD patients with low MCHC but without anemia. MCHC was not found to be an independent predictor of mortality, but there was a significant correlation between MCHC and survival in patients without anemia.eninfo:eu-repo/semantics/openAccessMortalityCOPDanemiaMCHCArticle10.53446/actamednicomedia.1143661611131191161605