Eroglu, SemraCakmakliogullari, Elcin Kal2026-01-242026-01-2420240104-42301806-9282https://doi.org/10.1590/1806-9282.20240138https://hdl.handle.net/20.500.12868/5238OBJECTIVE: There is growing evidence suggesting a relationship between periostin levels, inflammation, and ovarian dysfunction. In this prospective case-control study, we aimed to investigate serum periostin levels and their relationship with metabolic parameters in patients with polycystic ovary syndrome. METHODS: We conducted a prospective case-control study involving 45 polycystic ovary syndrome patients and 45 control subjects, matched in a 1:1 ratio. Serum samples collected from both study and control groups were analyzed using enzyme-linked immunosorbent assay. RESULTS: The demographic characteristics were similar between the polycystic ovary syndrome and control groups (p>0.05). Periostin levels were significantly higher in patients with polycystic ovary syndrome compared with the control group (4.67 +/- 2.46 vs. 2.60 +/- 1.41 ng/mL, respectively; p=0.000). CONCLUSION: Our study revealed a significant elevation in periostin levels among polycystic ovary syndrome patients compared with controls. These findings suggest that periostin could serve as a potential marker for assessing disease severity in polycystic ovary syndrome patients.eninfo:eu-repo/semantics/openAccessPolycystic ovary syndromePeriostinInflammationInsulin resistanceArticle10.1590/1806-9282.20240138706390459652-s2.0-85199376165Q2WOS:001276106600001Q2