Pala, MukaddesAltan, MehmetHanikoğlu, FerahatNeşelioğlu, SalimErel, ÖzcanMetin, Gökhan2022-10-032022-10-032022https://dergipark.org.tr/tr/download/article-file/2182572https://hdl.handle.net/20.500.12868/1761Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels. Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method. Results: In the EG, total thiol levels were significantly higher compared to the CG (p<0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p<0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant. Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress.eninfo:eu-repo/semantics/openAccessSwimmingOxidative stressThiol/disulfide homeostasisIschemiamodified albuminArticle10.30565/medalanya.105542462120125