Sozen, Mehmet EnesAkkaya, ÖzgürSavas, Hasan BasriKarahan, Oguz2026-01-242026-01-2420231300-17792687-2781https://search.trdizin.gov.tr/tr/yayin/detay/1170821https://doi.org/10.53394/akd.1015590https://hdl.handle.net/20.500.12868/3820Objective: Acrylamide (ACR) is formed spontaneously during the preparation of carbohydrate-containing foods by exposure to high heat and can be found in large amounts in processed ready-made foods like potato crisps, biscuits, crackers, and bread. ACR is a toxic substance and increases oxidative stress. The aim of the study is to show the effects of ACR exposure at different doses on angiogenesis and oxidant-antioxidant balance in the chorioallantoic membrane (CAM) model. Methods: Two different concentrations of ACR were prepared (10-3 M and 10-4 M). Pellets were placed on the CAM of the embryos. Liquid samples were taken from fertilized chicken eggs before and after the experiment. Anti-angiogenic effects were evaluated through the window that was opened on the eggshell. Results: The 10-4 M ACR group caused anti-angiogenic effects (average score 0.3) which were higher than the control group, but these changes were not statistically significant. The 10-3 M ACR group caused moderate anti-angiogenic effects (average score 0.6). The 10-6 M Bevacizumab group caused powerful anti-angiogenic effects (average score 1). There is a significant increase in total oxidant capacity (TOC) and oxidative stress index (OSI) values in 10-3 M ACR and 10-4 M ACR groups, compared to the control group. Although there was a numerical increase in TOC and OSI values in 10-3 M ACR group compared to 10-4 M ACR group, this increase was not statistically significant. Conclusion: This study is the first to investigate the anti-angiogenic effects of ACR and is one of the first to investigate oxidative stress in the CAM model. ACR exposure increased oxidative stress in the CAM model and showed a dose-dependent anti-angiogenic effect.eninfo:eu-repo/semantics/openAccessAntioxidantAngiogenesisAcrylamideOxidantChorioallantoic membrane modelArticle10.53394/akd.1015590921621681170821