Avnioğlu, SedaGüngör, MeltemKurutaş, ErgülÖztürk, ÜnalDemirhan, İlterBakaris, SevgiVelioğlu, Halil AzizÇankaya, ŞeydaYuluğ, Burak2022-09-122022-09-122022https://hdl.handle.net/20.500.12868/1528https://sciendo.com/article/10.2478/rrlm-2021-0036Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.eninfo:eu-repo/semantics/openAccessresveratrolischemia/reperfusion injuryantioxidantoxidative stressheartArticle10.2478/rrlm-2021-0036301918Q4