Gunal, Mehmet YalcinÇankaya, SeydaTönük, Şükrü BurakÖzdemir, Ekrem MusaŞakul, Ayşe Arzu Sayın2026-01-242026-01-2420192587-0319https://search.trdizin.gov.tr/tr/yayin/detay/376949https://doi.org/10.30565/medalanya.632455https://hdl.handle.net/20.500.12868/3774Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that \"TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect\".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.eninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar Deneysel,Genel ve Dahili Tıp,PatolojiArticle10.30565/medalanya.63245533306310376949