Erel, EnsarTunc, Merve Goksin KaraaslanKoytepe, SuleymanAtes, BurhanYilmaz, Ismet2026-01-242026-01-2420250003-27191532-236Xhttps://doi.org/10.1080/00032719.2024.2420907https://hdl.handle.net/20.500.12868/5844Caffeic acid (CA) based polyurethane (PU) films were synthesized and characterized for the simultaneous determination of melatonin (MT) and serotonin (5-HT). The CA based PUs were synthesized using a polyol mixture of 4,4'-diisocyanodiphenylmethane (MPI), polyethylene glycol-200 (PEG), and CA. The PEG-CA monomer units in the polyol were varied in molar ratios of 99:1, 97:3, 95:5, and 90:10. The synthesized PUs were characterized by FTIR spectroscopy and thermal analysis. These CA based PU films were coated onto screen-printed carbon electrodes (SPCEs) with varying thicknesses and used for the simultaneous determination of MT and 5-HT. Electrochemical responses of MT and 5-HT were evaluated using differential pulse voltammetry. The limit of detection and correlation coefficient for MT were 280 mu M and 0.9797, respectively, while for 5-HT, the detection was 150 mu M with a correlation coefficient of 0.9690. The precision, expressed as the relative standard deviation was 2.633% for MT and 4.668% for 5-HT. These findings suggest that CA based PU-modified electrodes hold potential in medical and biomedical applications.eninfo:eu-repo/semantics/closedAccessCaffeic aciddifferential pulse voltammetry (DPV)electrochemical analysismelatoninpolyurethaneserotoninvoltammetric sensorArticle10.1080/00032719.2024.2420907581525512568WOS:001347009900001Q3