Toktay, ErdemSelli, JaleGürbüz, Muhammed AliTaştan, Tuğba BalUğan, Rüstem AnılUn, HarunHalıcı, Zekai2021-02-192021-02-1920202008-38662008-3874https://doi.org/10.22038/ijbms.2020.48294.11089https://hdl.handle.net/20.500.12868/491UGAN, RUSTEM ANIL/0000-0002-4837-2343Objective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques. Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin beta 3, integrin alpha v beta 3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups. In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner. Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein.eninfo:eu-repo/semantics/openAccessDaidzeinEndometrial ReceptivityGenisteinRatSoy IsoflavonoidsArticle10.22038/ijbms.2020.48294.1108923121603160933489035Q2WOS:000579887700013Q3