dc.contributor.author | Sakul, Arzu | |
dc.contributor.author | Ozansoy, Mehmet | |
dc.contributor.author | Elibol, Birsen | |
dc.contributor.author | Ayla, Şule | |
dc.contributor.author | Günal, Mehmet Yalçın | |
dc.contributor.author | Yozgat, Yasemin | |
dc.contributor.author | Kılıç, Ülkan | |
dc.date.accessioned | 2021-02-19T21:29:05Z | |
dc.date.available | 2021-02-19T21:29:05Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1300-0152 | |
dc.identifier.issn | 1303-6092 | |
dc.identifier.uri | https://doi.org/10.3906/biy-1902-77 | |
dc.identifier.uri | https://app.trdizin.gov.tr/makale/TXpNMk1EUXlNZz09 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/962 | |
dc.description.abstract | The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice. Squalene (100 mg/kg/day) was administered orogastrically to mice for 10 days. Following sacrification, molecular alterations were investigated as analysis of the levels of oxidative stress index (OSI), inflammatory cytokines and cell survival-related proteins in addition to histopathological examinations in mice kidney tissue. The level OSI and Interferon-gamma (IFN-?) decreased in the cisplatin and squalene cotreated mice compared to cisplatin-treated mice. Squalene treatment also increased the activation of protein kinase B (AKT). Furthermore, cisplatin-induced inactivation of mammalian target of rapamycin (mTOR) and histopathological damages were reversed by squalene. It may be suggested that squalene ameliorated the cisplatin-induced histopathological damages in the kidney | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Biyoloji | en_US |
dc.title | Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ | en_US |
dc.contributor.institutionauthor | 0-belirlenecek | |
dc.identifier.doi | 10.3906/biy-1902-77 | |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 179 | en_US |
dc.identifier.endpage | 188 | en_US |
dc.relation.journal | Turkish Journal of Biology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |