Diclofenac sodium treatment ameliorates extrapancreatic organ injuries in a murine model of acute pancreatitis induced by caerulein
dc.contributor.author | Çakır, Özlem Özer | |
dc.contributor.author | Fındık, Sıddıka | |
dc.date.accessioned | 2021-02-19T21:16:17Z | |
dc.date.available | 2021-02-19T21:16:17Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1687-6121 | |
dc.identifier.issn | 1687-630X | |
dc.identifier.uri | https://doi.org/10.1155/2018/9829208 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/359 | |
dc.description | FINDIK, SIDDIKA/0000-0002-3364-7498 | en_US |
dc.description | WOS: 000449871200001 | en_US |
dc.description | PubMed: 30515205 | en_US |
dc.description.abstract | Aim. We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice. Methods. A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment. Results. Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P < 0 001, P < 0 001, P < 0 001, P < 0 001, and P = 0 048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P < 0 001, P < 0 001, P < 0 001, P = 0 030, and P < 0 001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P = 0 008, P = 0 014, and P < 0 001, respectively); and mean congestion and hydropic degeneration scores in the liver (P = 0 029 and P = 0 002, respectively). Conclusion. Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Hindawi Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Diclofenac sodium treatment ameliorates extrapancreatic organ injuries in a murine model of acute pancreatitis induced by caerulein | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ | en_US |
dc.contributor.institutionauthor | 0-belirlenecek | |
dc.identifier.doi | 10.1155/2018/9829208 | |
dc.identifier.volume | 2018 | en_US |
dc.relation.journal | Gastroenterology Research And Practice | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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