dc.contributor.author | Toktay, Erdem | |
dc.contributor.author | Taştan, Tuğba Bal | |
dc.contributor.author | Gürbüz, Muhammet Ali | |
dc.contributor.author | Erbaş, Elif | |
dc.contributor.author | Demir, Özlem | |
dc.contributor.author | Ulgan, Rüstem Anıl | |
dc.contributor.author | Selli, Jale | |
dc.date.accessioned | 2024-10-24T08:16:07Z | |
dc.date.available | 2024-10-24T08:16:07Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/35655595/ | |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/2498 | |
dc.description.abstract | Objective(s): We thought that astaxanthin (ASX) might be a protective agent in oxidative stress
damage that develops against ischemia and reperfusion injury in the rat ovary.
Materials and Methods: The experimental groups consisted of healthy, I (Ischemia), I+ASX50, I+ASX100,
I/R (Ischemia/Reperfusion), I/R+ ASX50, and I/R+ ASX100. Vascular clamps were applied to the ovaries
for 3 hr to induce ischemia. For the reperfusion groups, the clamps were opened and blood flow was
restored to the ovaries for 3 hr. At the end of the experiment, biochemical, histopathological, and
immunohistochemical analyses were made from the tissue samples taken.
Results: While MDA levels increased significantly in I and I/R groups, SOD levels decreased. It was
found that ASX significantly decreased MDA levels and increased SOD activity in treatment groups
depending on the dose. Caspase 3, IL-1 β, and IL-6 expressions were severely increased in ischemia
and I/R groups, while the severity of I+ASX50 and I/R+ASX100 immunoreactivity was decreased.
While severe hemorrhage areas were observed in I and IR groups, minimal hemorrhage areas were
observed in the treatment groups, especially in I/R+ASX100 groups. In addition, inflammatory cells
and necrotic cells in the I/R group were not observed in I/R+ASX50 and I/R+ASX100 groups.
Conclusion: As a result, it was determined that ASX has a strong protective role against oxidative
damage in the treatment of ovarian ischemia-reperfusion injury | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.22038/IJBMS.2022.61289.13559 Full text linksCite | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Astaxanthin | en_US |
dc.subject | Ischemia | en_US |
dc.subject | Ovary | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Rat | en_US |
dc.subject | Reperfusion | en_US |
dc.title | Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 179 | en_US |
dc.identifier.endpage | 178 | en_US |
dc.relation.journal | Iranian Journal of Basic Medical Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |