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dc.contributor.authorToktay, Erdem
dc.contributor.authorTaştan, Tuğba Bal
dc.contributor.authorGürbüz, Muhammet Ali
dc.contributor.authorErbaş, Elif
dc.contributor.authorDemir, Özlem
dc.contributor.authorUlgan, Rüstem Anıl
dc.contributor.authorSelli, Jale
dc.date.accessioned2024-10-24T08:16:07Z
dc.date.available2024-10-24T08:16:07Z
dc.date.issued2022en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35655595/
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2498
dc.description.abstractObjective(s): We thought that astaxanthin (ASX) might be a protective agent in oxidative stress damage that develops against ischemia and reperfusion injury in the rat ovary. Materials and Methods: The experimental groups consisted of healthy, I (Ischemia), I+ASX50, I+ASX100, I/R (Ischemia/Reperfusion), I/R+ ASX50, and I/R+ ASX100. Vascular clamps were applied to the ovaries for 3 hr to induce ischemia. For the reperfusion groups, the clamps were opened and blood flow was restored to the ovaries for 3 hr. At the end of the experiment, biochemical, histopathological, and immunohistochemical analyses were made from the tissue samples taken. Results: While MDA levels increased significantly in I and I/R groups, SOD levels decreased. It was found that ASX significantly decreased MDA levels and increased SOD activity in treatment groups depending on the dose. Caspase 3, IL-1 β, and IL-6 expressions were severely increased in ischemia and I/R groups, while the severity of I+ASX50 and I/R+ASX100 immunoreactivity was decreased. While severe hemorrhage areas were observed in I and IR groups, minimal hemorrhage areas were observed in the treatment groups, especially in I/R+ASX100 groups. In addition, inflammatory cells and necrotic cells in the I/R group were not observed in I/R+ASX50 and I/R+ASX100 groups. Conclusion: As a result, it was determined that ASX has a strong protective role against oxidative damage in the treatment of ovarian ischemia-reperfusion injuryen_US
dc.language.isoengen_US
dc.relation.isversionof10.22038/IJBMS.2022.61289.13559 Full text linksCiteen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectIschemiaen_US
dc.subjectOvaryen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.subjectReperfusionen_US
dc.titlePotential protective effect of astaxanthin on ovary ischemia-reperfusion injuryen_US
dc.typearticleen_US
dc.contributor.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.volume25en_US
dc.identifier.issue2en_US
dc.identifier.startpage179en_US
dc.identifier.endpage178en_US
dc.relation.journalIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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