dc.contributor.author | Avcı, Sema | |
dc.contributor.author | Kuşçu, Nilay | |
dc.contributor.author | Kılınç, Leyla | |
dc.contributor.author | Üstünel, İsmail | |
dc.date.accessioned | 2024-10-24T08:14:17Z | |
dc.date.available | 2024-10-24T08:14:17Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/34927491/ | |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/2497 | |
dc.description.abstract | Although it is thought that there is a close relationship between Notch signal and preterm birth, the functioning of this
mechanism in the cervix is unknown. The efficacy of surfactants and prostaglandin inhibitors in preterm labor is also still
unclear. In this study, 48 female CD-1 mice were distributed to pregnant control (PC), Sham, PBS, indomethacin (2 mg/
kg; intraperitoneally), lipopolysaccharides (LPS) (25 μg/100 μl; intrauterine), LPS + IND, and Surfactant Protein A Block
(SP-A Block: SP-A B; the anti-SP-A antibody was applied 20 µg/100μl; intrauterine) groups. Tissues were examined by
immunohistochemistry, immunofluorescence, and Western blot analysis. LPS administration increased the expression
of N1 Dll-1 and Jagged-2 (Jag-2). Although Toll-like receptor (Tlr)-2 significantly increased in the LPS-treated and SPA-blocked groups, Tlr-4 significantly increased only in the LPS-exposed groups. It was observed that Jag-2 is specifically
expressed by mast cells. Overall, this experimental model shows that some protein responses increase throughout the
uterus, starting at a specific point on the cervix epithelium. Surfactant Protein A, which we observed to be significantly
reduced by LPS, may be associated with the regulation of the epithelial response, especially during preterm delivery due to
infection. On the contrary, prostaglandin inhibitors can be considered an option to delay infection-related preterm labor
with their dose-dependent effects. Finally, the link between mast cells and Jag-2 could potentially be a control switch for
preterm birth. (J Histochem Cytochem 70:121–138, 2022) | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1369/00221554211061615 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cervix | en_US |
dc.subject | Notch Signaling Pathway | en_US |
dc.subject | Preterm Birth | en_US |
dc.subject | Prostaglandins | en_US |
dc.subject | Surfactant Protein A | en_US |
dc.title | Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.identifier.volume | 70 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 121 | en_US |
dc.identifier.endpage | 138 | en_US |
dc.relation.journal | Journal of Histochemistry & Cytochemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |