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dc.contributor.authorAvcı, Sema
dc.contributor.authorKuşçu, Nilay
dc.contributor.authorKılınç, Leyla
dc.contributor.authorÜstünel, İsmail
dc.date.accessioned2024-10-24T08:14:17Z
dc.date.available2024-10-24T08:14:17Z
dc.date.issued2022en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/34927491/
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2497
dc.description.abstractAlthough it is thought that there is a close relationship between Notch signal and preterm birth, the functioning of this mechanism in the cervix is unknown. The efficacy of surfactants and prostaglandin inhibitors in preterm labor is also still unclear. In this study, 48 female CD-1 mice were distributed to pregnant control (PC), Sham, PBS, indomethacin (2 mg/ kg; intraperitoneally), lipopolysaccharides (LPS) (25 μg/100 μl; intrauterine), LPS + IND, and Surfactant Protein A Block (SP-A Block: SP-A B; the anti-SP-A antibody was applied 20 µg/100μl; intrauterine) groups. Tissues were examined by immunohistochemistry, immunofluorescence, and Western blot analysis. LPS administration increased the expression of N1 Dll-1 and Jagged-2 (Jag-2). Although Toll-like receptor (Tlr)-2 significantly increased in the LPS-treated and SPA-blocked groups, Tlr-4 significantly increased only in the LPS-exposed groups. It was observed that Jag-2 is specifically expressed by mast cells. Overall, this experimental model shows that some protein responses increase throughout the uterus, starting at a specific point on the cervix epithelium. Surfactant Protein A, which we observed to be significantly reduced by LPS, may be associated with the regulation of the epithelial response, especially during preterm delivery due to infection. On the contrary, prostaglandin inhibitors can be considered an option to delay infection-related preterm labor with their dose-dependent effects. Finally, the link between mast cells and Jag-2 could potentially be a control switch for preterm birth. (J Histochem Cytochem 70:121–138, 2022)en_US
dc.language.isoengen_US
dc.relation.isversionof10.1369/00221554211061615en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCervixen_US
dc.subjectNotch Signaling Pathwayen_US
dc.subjectPreterm Birthen_US
dc.subjectProstaglandinsen_US
dc.subjectSurfactant Protein Aen_US
dc.titleRelationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birthen_US
dc.typearticleen_US
dc.contributor.departmentALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.identifier.volume70en_US
dc.identifier.issue2en_US
dc.identifier.startpage121en_US
dc.identifier.endpage138en_US
dc.relation.journalJournal of Histochemistry & Cytochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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