dc.contributor.author | Sarıcaoğlu, Mevhibe | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Toprak, Güven | |
dc.contributor.author | Helvacı Yılmaz, Nesrin | |
dc.contributor.author | Yuluğ, Burak | |
dc.date.accessioned | 2024-10-24T06:20:18Z | |
dc.date.available | 2024-10-24T06:20:18Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/34649492/ | |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/2483 | |
dc.description.abstract | Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA would have beneficial effects on motor and behavioural outcomes in freezing of gait. To test this hypothesis, we examined the left pre-SMA stimulating effect of repetitive Transcranial Magnetic Stimulation (rTMS) on motor, cognitive and behavioural parameters in Parkinson's patients with FOG.
Methods: The study included 20 Parkinson's patients with FOG (3 females, 17 males) who received the left Pre-SMA rTMS procedure. The clinical assessments were performed on all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions.
Results & discussion: We found significant improvements in motor, cognitive and behavioural symptoms (p<0.05). The main finding of our study is that Pre-SMA is an attractive stimulation area leading to critical improvement of symptoms of Parkinson's patients with FOG.
Conclusion: The high-frequency rTMS stimulation over the left preSMA has a restorative effect on the motor, cognitive and behavioural symptoms of Parkinson's patients with FOG. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | DOI: 10.2174/1871530321666211014170107 Full text linksCite | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Freezing of Gait | en_US |
dc.subject | Behavioural Symptoms | en_US |
dc.subject | Cognitive Symptoms | en_US |
dc.subject | Motor Symptoms | en_US |
dc.subject | Parkinson’s Disease | en_US |
dc.subject | Presupplementary Area | en_US |
dc.subject | Repetitive Transcranial Magnetic Stimulation | en_US |
dc.title | The Multifactorial Role of Pre-supplementary Motor Area Stimulation in the Freezing of Gait: An Alternative Strategy to the Classical Drug-Target Approach | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 518 | en_US |
dc.identifier.endpage | 524 | en_US |
dc.relation.journal | Endocr Metab Immune Disord Drug Targets | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |