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dc.contributor.authorAslaner, Oktay
dc.date.accessioned2024-10-24T06:16:43Z
dc.date.available2024-10-24T06:16:43Z
dc.date.issued2022en_US
dc.identifier.urihttps://karger.com/ear/article-abstract/28/1/41/823379/Comparison-of-Oxidative-Effects-of-Electronic?redirectedFrom=fulltext
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2482
dc.description.abstractObjective: Cigarette smoking is a life-threatening habit that has rapidly spread in every socioeconomic part of the public worldwide. There exist mechanisms of nicotine delivery available to use in the hope of halting cigarette smoking, and the electronic cigarette (EC) is one of the common methods used for tobacco smoking replacement. This study aimed to investigate experimentally the oxidative effects of tobacco smoke and EC smoke which contain nicotine. Method: We constructed smoke circuit rooms for exposing the rats to EC or tobacco smoke. Three groups were created, the control group (N = 8); the electronic cigarette group (N = 8), exposure to electronic cigarette smoke for 2 h per day; and the tobacco group (N = 8), exposure to traditional cigarette smoke for 2 h per day. After the first and second week of exposure, blood samples were obtained, and serum oxidative stress index (OSI), paraoxonase 1 (PON1) activity, and prolidase levels were evaluated. Results: Higher values of OSI and prolidase levels were detected in the first week of EC or tobacco smoke exposure in both study groups (p < 0.001) when compared with the control group, and partial decrements were observed in the second week. By contrast, elevated PON1 levels were observed in the second week after EC or tobacco smoke exposure. The highest OSI levels were observed in the tobacco smoke group (p < 0.001). The lowest values of PON1 levels were detected in the first week of the electronic cigarette smoke group, and this decremental value was statistically different than normal, the second week of the electronic cigarette smoke group, the first week of the traditional cigarette smoke exposure group, and the second week of the traditional cigarette smoke exposure group values (p < 0.000). Conclusion: Our results indicate that EC smoke induced oxidative stress. Therefore, ECs are potentially risky for human health and can lead to important health problems.en_US
dc.language.isoengen_US
dc.relation.isversionofhttps://doi.org/10.1159/000518204en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of Oxidative Effects of Electronic Cigarette and Tobacco Smoke Exposure Performed Experimentallyen_US
dc.typearticleen_US
dc.contributor.departmentALKÜ, Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.identifier.volume28en_US
dc.identifier.issue1en_US
dc.identifier.startpage41en_US
dc.identifier.endpage47en_US
dc.relation.journalEuropean Addiction Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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