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dc.contributor.authorÇankaya, Şeyda
dc.date.accessioned2022-11-30T05:46:21Z
dc.date.available2022-11-30T05:46:21Z
dc.date.issued2021en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/459554/the-association-of-non-motor-symptoms-with-motorsymptoms-in-parkinsons-disease
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2069
dc.description.abstractAim: Idiopathic Parkinson’s disease (IPD) is the second most common progressive neurodegenerative disorder and well known with typical motor impairment. Besides motor symptoms, non-motor symptoms (NMS) occur very frequently among patients with IPD. This study aims to assess the presence of non-motor symptoms with the severity of motor symptoms.Materials and Methods: Alaaddin Keykubat University Training and Research Hospital’s database has been screened for identifying patients with IPD from 2015-2019. The patients’ motor symptom, NMS, and Hoehn & Yahr stage (H&Y stage) were assessed with the Movement Disorder Society - Unified Parkinson’s Disease Rating Scale (MDS-UPDRS).Results: A total of 50 IPD patients were analyzed. Analysis by NMS part of MDS-UPDRS (Part I) showed that NMS was present in 99.7% of patients. NMS part score was positively correlated with H&Y stages and total motor scores of MDS-UPDRS (part II-III). The most common symptoms were pain (84%), daytime sleepiness (78%), and urinary problems (76%). Significantly, there was an association between motor impairment, H&Y, and the following NMS items; hallucinations/psychosis, depressed mood, daytime sleepiness, urinary problems, constipation, light-headedness on standing, and fatigue (p<0.05, Spearman’s rho). Conclusions: Considering our data suggested that almost all patients with PD experience NMS. NMS are mostly worsened with exacerbation of MS (motor symptoms) and H&Y in cases. These findings will help understand the clinical aspect of PD and may improve personalized medicine and research in PD.en_US
dc.language.isoturen_US
dc.relation.isversionof10.5455/annalsmedres.2021.03.271en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIdiopathic Pankinson's Diseaseen_US
dc.subjectMDS-UPDRSen_US
dc.subjectMotor Symptomsen_US
dc.subjectNon-Motor Symptomsen_US
dc.titleThe association of non-motor symptoms with motorsymptoms in parkinson’s diseaseen_US
dc.typearticleen_US
dc.contributor.departmentALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.identifier.volume28en_US
dc.identifier.issue8en_US
dc.identifier.startpage1577en_US
dc.identifier.endpage1582en_US
dc.relation.journalAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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