The Relationship of Learning and Memory Disfunction with NEURL1 and RGS14 Genes in Patients with Autism Spectrum Disorders
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info:eu-repo/semantics/openAccessDate
2022Author
Eciroğlu, HamiyetŞener, Elif Funda
Öztop, Didem Behice
Özmen, Sevgi
Kaan, Dilek
Yusuf, Özkul
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Aim: We aimed to evaluate the relationship between learning-memory difficulties
and NEURL1 and RGS14 genes in patients with autism spectrum disorders (ASD).
Method: Forty children with ASD (20 ASD, 20 high functioning autism (HFA)) and 20
healthy controls were enrolled in this study. NEURL1 and RGS14 gene expressions
in blood samples of volunteers were assessed by quantitative Real-Time PCR (qRTPCR). The clinical and demographical findings in patients were determined and
examined in relation to the gene expressions.
Results: According to our findings, NEURL1 gene expression was decreased in both
patient groups compared to the control (p<0.05). No significant difference between
the groups in terms of the RGS14 gene (p>0.05). A statistically significant correlation
was found between learning and memory difficulties and RGS14 gene expression in
HFA patients (p=0.045). A positive correlation was observed between NEURL1 and
RGS14 gene expressions of ASD patients (p=0.032, r=0,59).
Conclusion: In this study, we showed that the NEURL1 gene may affect learning and
memory difficulties in ASD patients. Nonetheless, we recommend that both genes
be studied with more patients and preferably with brain tissues. These genes were
evaluated for the first time in a clinical study on autism, and we believe that they will
contribute to the literature in this respect.
Source
Acta Medica AlanyaVolume
6Issue
2URI
https://dergipark.org.tr/tr/download/article-file/2511272https://hdl.handle.net/20.500.12868/1774