Effects of LDD and CAPE Administration on Total Antioxidant and Total Oxidant Levels in Experimental Periodontitis Model of Rat Brain
Abstract
Aim: Observing the effects of caffeic acid phenethyl ester (CAPE) and/or low dose
doxycycline (LDD) on total antioxidant and oxidant status of brain in experimental
periodontitis is the purpose of the study.
Methods: 48 male Wistar albino rats were designed as the following: control
group (C, n=8), periodontitis + CAPE group (PC, n=10), periodontitis + LDD (PD,
n=10), periodontitis + LDD + CAPE group (PCD, n=10), and periodontitis group (P,
n=10). The time period for the experiment was 14 days. 10 µmol/kg/day of CAPE
was administered using an intraperitoneal injection (IP). 10 mg/kg/day of LDD
was administered using an oral gavage method. Histopathological changes were
evaluated.
Results: Beneficial results were seen in all of the groups after LDD and/or CAPE
administration on decreasing the alveolar bone loss level and oxidative stress. All of
the experimental groups showed signs of periodontitis with alveolar bone loss. The
P group leads with the most alveolar bone loss compared to the other periodontitis
groups and the lowest group was the PC group in the periodontitis groups. The
evolution of alveolar bone loss from high to low was that group P, group PD, group
PCD, group PC, and group C (P < 0.05). However, there is no statistical difference
between brain total antioxidant status and brain total oxidant status average values
according to brain groups (p > 0.05).
Conclusion: The combination of LDD and CAPE are not significantly different when
applied alone or together on oxidative status. But both of the agents have beneficial
effects on reducing the oxidative stress and tissue damages.
Source
Acta Medica AlanyaVolume
6Issue
1URI
https://dergipark.org.tr/tr/download/article-file/2171716https://hdl.handle.net/20.500.12868/1757