dc.contributor.author | Kankılıç, Nazım | |
dc.date.accessioned | 2022-10-03T07:28:05Z | |
dc.date.available | 2022-10-03T07:28:05Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/1750 | |
dc.description.abstract | Aim: Carbohydrate antigen-125 (CA-125) is a well-known marker for mesenchymal
cell activation. It is being investigated as a predictive marker for cardiac pathologies
due to pericardial or pleural mesenchymal cell activation. In this study, the relationship
between left ventricular diastolic diameter (LVDd) and ejection fraction (EF) and
serum CA-125 levels was investigated.
Material and Method: Thirty-eight patients who underwent coronary artery bypass
graft operation were included in the study. LVDd and EF values were calculated.
Routine blood parameters and serum CA-125 levels were obtained from blood
samples. Patients were divided into groups according to LVDd (LVDd <50mm vs.
≥50mm) and EF (EF <50% vs. EF≥50%).
Results: Among the low (<50%) and high (≥50%) EF groups, serum neutrophil, mean
platelet volume (MPV), lactate dehydrogenase (LDH), aspartate aminotransferase
(AST), troponin-I, triglyceride, and very low-density lipoprotein (VLDL) levels were
statistically different (p<0.05). However, no statistical difference was observed
between the low (<50mm) and high (≥50mm) LVDd groups in other blood parameters
except for serum CA-125 levels (p>0.05). Higher serum CA-125 levels were obtained
in patients with a high left ventricular diastolic diameter (≥50mm) (p<0.05). In addition,
CA-125 was found to be an important predictor of left ventricular diastolic diameter
with an optimal cut-off value of 0.644 kU/L (60% sensitivity and 78.3% specificity).
Conclusion: According to our results, increased serum CA-125 level is an
independent predictor of higher LVDd and may be a good indicator of left ventricular
functions. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.30565/medalanya.972281 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | CA-125 | en_US |
dc.subject | Left ventricle diastolic dimension | en_US |
dc.subject | Ejection fraction | en_US |
dc.title | Predictive Value of Carbohydrate Antigen-125 in Determining the Left Ventricular Diastolic Dysfunction | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 58 | en_US |
dc.identifier.endpage | 63 | en_US |
dc.relation.journal | Acta Medica Alanya | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Başka Kurum Yazarı | en_US |