Predictive Value of Carbohydrate Antigen-125 in Determining the Left Ventricular Diastolic Dysfunction

Abstract

Aim: Carbohydrate antigen-125 (CA-125) is a well-known marker for mesenchymal cell activation. It is being investigated as a predictive marker for cardiac pathologies due to pericardial or pleural mesenchymal cell activation. In this study, the relationship between left ventricular diastolic diameter (LVDd) and ejection fraction (EF) and serum CA-125 levels was investigated. Material and Method: Thirty-eight patients who underwent coronary artery bypass graft operation were included in the study. LVDd and EF values were calculated. Routine blood parameters and serum CA-125 levels were obtained from blood samples. Patients were divided into groups according to LVDd (LVDd <50mm vs. ≥50mm) and EF (EF <50% vs. EF≥50%). Results: Among the low (<50%) and high (≥50%) EF groups, serum neutrophil, mean platelet volume (MPV), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), troponin-I, triglyceride, and very low-density lipoprotein (VLDL) levels were statistically different (p<0.05). However, no statistical difference was observed between the low (<50mm) and high (≥50mm) LVDd groups in other blood parameters except for serum CA-125 levels (p>0.05). Higher serum CA-125 levels were obtained in patients with a high left ventricular diastolic diameter (≥50mm) (p<0.05). In addition, CA-125 was found to be an important predictor of left ventricular diastolic diameter with an optimal cut-off value of 0.644 kU/L (60% sensitivity and 78.3% specificity). Conclusion: According to our results, increased serum CA-125 level is an independent predictor of higher LVDd and may be a good indicator of left ventricular functions.