Assessment Of Tp-E Interval, Tp-E/Qt, Tp-E/Qtc Ratıos In Thalassemıa Major Patıents
Özet
Aim: Thalassemia major (TM) is a genetic hemoglobinopathy that causes chronic
hemolytic anemia. Repeated blood transfusions are needed for treatment. Iron
accumulation is used to predict the risk of ventricular arrhythmia. We designed this
study to compare the Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio, which are the
novel and reliable predictors that show ventricular repolarization, between the TM
patients and healthy control group.
Method: We included 97 TM patients who presented to our outpatient clinic for routine
cardiac check-up from March 2019 to June 2020 and 90 healthy volunteers. In addition
to the demographic and echocardiographic findings, patients’ electrocardiograms
(ECG) were retrospectively analyzed. Their serum ferritin, C reactive protein (CRP)
levels and neutrophil to lymphocyte ratios were recorded and compared.
Result: The Tp-e interval was 80 msn (60.0-80.0) in the group of thalassemia major
patients whereas it was 60 msn (50.0-70.0) (p<0.001) in the control group. The Tp-e/
QT ratio was 0.200 (0.160-0.225) in the TM group while it was 0.175(0.150-0.210) in
the control group (p=0.014). The Tp-e/QTc ratio was 0.180 (0.130-0.190) in the TM
group while it was 0.150 (0.130-0.180) in the control group (p=0.035). No correlation
was found between their serum ferritin levels and ECG parameters.
Conclusion: Prolonged Tp-e interval, Tp-e/QT ve Tp-e/QTc ratios on the ECG in
TM patients are associated with impaired ventricular repolarization due to excessive
cardiac iron deposition and ventricular arrhythmias. These simple but reliable
parameters can be used to predict the risk of arrhythmia
Kaynak
Acta Medica AlanyaCilt
6Sayı
1Bağlantı
https://dergipark.org.tr/tr/download/article-file/1836314https://hdl.handle.net/20.500.12868/1748