Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis
Abstract
Aim: The natural course of sarcoidosis is heterogeneous. There is no clear marker
that can predict the course of this disease and its characteristics over months/
years. We aimed to analyze our patients' data to identify a prediction parameter at
admission.
Methods: The patients with sarcoidosis and followed-up between 2015-01-01 and
2020-12-31 comprised the study group. The patients were staged by a Scadding
staging system. Improvement or deterioration in at least two of the clinical-laboratoryradiological parameters indicates regression, stable disease, progression, or relapse
of sarcoidosis.
Results: The study group comprised four cases (6.9%) defined as stage 0; fifteen
cases (25.86%) as stage 1; 39 cases (67.24%) were defined as stage 2. The
mean age at diagnosis was 40.84±13.56 in stage 0 + stage 1 group, while it was
48.05±13.36 in the stage 2 group (p=0.06). 74.1% of the cases were women. The
female/male ratio was found at 2.86. 57 out of 58 cases had a pathological diagnosis
(EBUS TBNA). While PFTs values and DLCO were significantly lower at advanced
stages but the same statistical significance was not identified between these values
and the clinical course of the disease. As a result of the multivariate analysis, it was
observed that only the presence of chest pain at admission affected the progression
of the disease in the follow-up period.
Conclusion: Sarcoidosis is a multi-systemic disease and there is no clear finding for
predicting the poor prognosis of the disease. We conclude that chest pain symptom at
admission is valuable predictive finding and can be used as a clue for the progression
at follow-up
Source
Acta Medica AlanyaVolume
6Issue
1URI
https://dergipark.org.tr/tr/download/article-file/1809627https://hdl.handle.net/20.500.12868/1747