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dc.contributor.authorGöktepe, Özge
dc.contributor.authorCantürk Tan, Fazile
dc.contributor.authorNarin, Figen
dc.contributor.authorYakan, Birkan
dc.date.accessioned2022-09-30T07:19:53Z
dc.date.available2022-09-30T07:19:53Z
dc.date.issued2021en_US
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/1476005
dc.identifier.urihttps://hdl.handle.net/20.500.12868/1725
dc.description.abstractAim: Varicocele, abnormal dilatation of pampiniform venous plexus, is classified into three groups: 1st, 2nd and 3rd grade. The aim of our research is to show the differences among the three different varicocele grades based on the results of their sperm DNA damage and blood biochemical parameters. Methods: We examined 30 patients which were classified into three groups: Group 1 (healthy), Group 2 (grades 1 and 2) and Group 3 (grade 3). The semen samples were examined in terms of DNA damage via comet assay. The blood samples were assessed using catalase (CAT), superoxide dismutase (SOD) enzyme activities and malondialdehyde (MDA) levels. Results: According to the comet findings, Group 2 and Group 3 parameters were significantly higher than Group 1 (p < 0.01). In the biochemical findings, we observed decreased CAT and SOD activities and an increased MDA level for Group 2 and Group 3. In our research, we showed that grades 1 and 2 had significant DNA damage in terms of infertility as much as grade 3. Conclusion: The results we derived indicate that the detection of DNA damage could be used as a predictor of infertility alongside routine semen and morphological analysis.en_US
dc.language.isoengen_US
dc.relation.isversionof10.30565/medalanya.849413:en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVaricoceleen_US
dc.subjectInfertilityen_US
dc.subjectSpermatozoaen_US
dc.subjectDNA damageen_US
dc.titleThe evaluation of sperm DNA damage in patients with different varicocele gradesen_US
dc.typearticleen_US
dc.contributor.departmentALKÜen_US
dc.identifier.volume5en_US
dc.identifier.issue2en_US
dc.identifier.startpage226en_US
dc.identifier.endpage233en_US
dc.relation.journalActa Medica Alanyaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Başka Kurum Yazarıen_US


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