dc.contributor.author | Göktepe, Özge | |
dc.contributor.author | Cantürk Tan, Fazile | |
dc.contributor.author | Narin, Figen | |
dc.contributor.author | Yakan, Birkan | |
dc.date.accessioned | 2022-09-30T07:19:53Z | |
dc.date.available | 2022-09-30T07:19:53Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.uri | https://dergipark.org.tr/tr/download/article-file/1476005 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12868/1725 | |
dc.description.abstract | Aim: Varicocele, abnormal dilatation of pampiniform venous plexus, is classified
into three groups: 1st, 2nd and 3rd grade. The aim of our research is to show the
differences among the three different varicocele grades based on the results of their
sperm DNA damage and blood biochemical parameters.
Methods: We examined 30 patients which were classified into three groups: Group
1 (healthy), Group 2 (grades 1 and 2) and Group 3 (grade 3). The semen samples
were examined in terms of DNA damage via comet assay. The blood samples were
assessed using catalase (CAT), superoxide dismutase (SOD) enzyme activities and
malondialdehyde (MDA) levels.
Results: According to the comet findings, Group 2 and Group 3 parameters were
significantly higher than Group 1 (p < 0.01). In the biochemical findings, we observed
decreased CAT and SOD activities and an increased MDA level for Group 2 and
Group 3. In our research, we showed that grades 1 and 2 had significant DNA
damage in terms of infertility as much as grade 3.
Conclusion: The results we derived indicate that the detection of DNA damage
could be used as a predictor of infertility alongside routine semen and morphological
analysis. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.30565/medalanya.849413: | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Varicocele | en_US |
dc.subject | Infertility | en_US |
dc.subject | Spermatozoa | en_US |
dc.subject | DNA damage | en_US |
dc.title | The evaluation of sperm DNA damage in patients with different varicocele grades | en_US |
dc.type | article | en_US |
dc.contributor.department | ALKÜ | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 226 | en_US |
dc.identifier.endpage | 233 | en_US |
dc.relation.journal | Acta Medica Alanya | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Başka Kurum Yazarı | en_US |