Systemic immune-inflammation index and high-sensitivity cardiac troponin T in acute coronary syndromes
Özet
Aim: Acute coronary syndromes (ACSs) are classified as ST-segment elevated
myocardial infarction (STEMI), non-ST-segment elevated myocardial infarction
(NSTEMI) and unstable angina pectoris (USAP). Cardiac troponins constitute the
cornerstone biomarkers for the laboratory diagnosis of ACS. In this study, we aimed
to investigate whether systemic immune-inflammation index (SII) is associated with
peak cardiac troponin T (TnT) levels in ACS.
Methods: Consecutive patients with ACS whose coronary angiography was
performed were included in the present study (n=397). Admission SII was determined
as platelet count x neutrophil count/lymphocyte count. Serum levels of cardiac
enzymes, including high-sensitivity TnT and creatine kinase-myocardial band (CKMB), were measured at the time of admission and repeated daily during patients’
hospital stay.
Results: Patients were categorized as namely STEMI (n=92) and NSTEMI/USAP
(n=141). The findings obtained in this study showed that the median of SII levels was
higher in STEMI than NSTEMI/USAP at a significant level. Correlation analysis of SII
with various clinical and laboratory parameters demonstrated a significant correlation
with C-reactive protein, peak CK-MB (r=0.52, p<0.001), peak TnT (r=0.49, p<0.001)
and left ventricular ejection fraction (r= -0.48, p<0.001). Multivariate linear regression
analysis identified age and log-SII (Beta Coefficient: 1.29, 95% Confidence Interval:
0.93-1.66, p<0.001) as independent predictors of peak TnT levels.
Conclusion: SII is an independent predictor of peak TnT levels and significantly
correlates with peak CK-MB levels in patients with ACS. SII significantly and inversely
correlates with left ventricular systolic functions.
Kaynak
Acta Medica AlanyaCilt
5Sayı
2Bağlantı
https://dergipark.org.tr/tr/download/article-file/1765464https://hdl.handle.net/20.500.12868/1724