The relationship of inflammatory indicators and metabolic syndrome with gonarthrotic cartilage degeneration: A novel glance
Abstract
Objective: The combination of a number of metabolic abnormalities such as high
body mass index (BMI), central obesity, low high-density lipoprotein (HDL), high
triglycerides, high blood pressure, and hyperglycemia is defined as metabolic
syndrome (MetS). This study aimed to clarify the effect of metabolic syndrome
components on joint degeneration and investigate the relationship between systemic
inflammatory response and end-stage osteoarthritis clinical course.
Material and Methods: Fifty-seven patients, who underwent total knee arthroplasty
due to primary knee osteoarthritis, were classified according to metabolic syndrome
diagnosis criteria. Their medial and lateral tibial plateau specimens were graded
histopathologically according to Osteoarthritis Research Society International scoring
system (OARSI).
Results: 33 patients were performed right total arthroplasty (57.9%), 24 were
performed left (42.1%). The mean age was 68.46 ± 6.88 (range 57 to 85). The
mean BMI value was 30.31 ± 5.26 (range 20.2 to 48). According to the International
Diabetes Foundation (IDF) 2005 metabolic syndrome (MetS) diagnostic criteria;
31.5% (n = 18) of the patients did not have MetS, while 68.4% (n = 39) had. There
was no statistically significant relationship between tibial plateau OARSI scores and
metabolic syndrome (p> 0.05). Besides, these OARSI scores and the operation side,
hypertension, and BMI had no statistically significant relationship (p> 0.05).
Conclusions: Metabolic syndrome components may play a role in initiating the
osteoarthritic process via adipokines, but we could not identify certain effects of
pro-inflammatory mediator components on tibial plateau cartilage degeneration with
histopathological scores till end-stage arthritic progress.
Source
Acta Medica AlanyaVolume
5Issue
2URI
https://dergipark.org.tr/tr/pub/medalanya/issue/64601/882840https://hdl.handle.net/20.500.12868/1710