Yazar "Yılmaz, Sinem" için listeleme
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Design, synthesis, biological evaluation and molecular docking of novel molecules to PARP-1 enzyme
Tok, Fatih; Kaymakçıoğlu Bedia; İlhan, Recep; Yılmaz, Sinem; Ballar Kırmızıbayrak, Petek; Taşkın Tok, Tuğba (TUBITAK, 2019)Poly (ADP-ribose) polymerase (PARP) enzyme catalyzes the transfer of ADP-ribose into target proteins. Therefore, PARP is responsible for DNA repair, cell proliferation, and cell death. In this study, potential PARP enzyme ... -
Microbial transformation of cycloastragenol and astragenol by endophytic fungi isolated from astragalus species
Ekiz, Güner; Yılmaz, Sinem; Yusufoğlu, Hasan; Kırmızıbayrak, Petek Ballar; Bedir, Erdal (American Chemical Society, 2019)Biotransformation of Astragalus sapogenins (cycloastragenol (1) and astragenol (2)) by Astragalus species originated endophytic fungi resulted in the production of five new metabolites (3, 7, 10, 12, 14) together with 10 ... -
Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells
Khan, Nasar; Yılmaz, Sinem; Aksoy, Semiha; Uzel, Ataç; Tosun, Çiğdem; Kırmızıbayrak, Petek Ballar; Bedir, Erdal (Elsevier Ireland Ltd, 2019)Polyether compounds, a large group of biologically active metabolites produced by Streptomyces species have been reported to show a variety of bioactivity such as antibacterial, antifungal, antiparasitic, antiviral, and ... -
The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity
Aging is well-characterized by the gradual decline of cellular functionality. As redox balance, proteostasis, and telomerase systems have been found to be associated with aging and age-related diseases, targeting these ...
