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Agomelatine could prevent brain and cerebellum injury against LPS-induced neuroinflammation in rats
Savran, Meltem Karadeniz; Aslankoç, Rahime; Özmen, Özlem; Erzurumlu, Yalçın; Savas, Hasan Basri; Temel, Esra Nurlu; Bortepe, S. (Academic Press Ltd- Elsevier Science Ltd, 2020)Sepsis, systemic hyper-inflammatory immune response, causes the increase of morbidity and mortality rates due to multi-organ diseases such as neurotoxicity. Lipopolysaccharide (LPS) induces inflammation, oxidative stress ... -
Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity
Aşçı, Halil; Özmen, Özlem; Erzurumlu, Yalçın; Savaş, Hasan Basri; Temel, Esra Nurlu; İçten, Pelin; Hasseyid, N. (Taylor & Francis Ltd, 2020)We investigated the antioxidant, anti-inflammatory and anti-apoptotic effects of pregabalin (PREG) on lipopolysaccharide (LPS) induced sepsis related cardiotoxicity via NF-k beta pathways. We used 24 female Wistar albino ... -
The impact of prophylactic lacosamide on LPS-induced neuroinflammation in aged rats
Savran, Mehtap; Özmen, Özlem; Erzurumlu, Yalçın; Savaş, Hasri Basri; Aşçı, S.; Kaynak, M. (Springer/Plenum Publishers, 2019)Sepsis-induced central nervous system damage is called sepsis-associated encephalopathy (SAE). In addition to neuroinflammation, oxidative stress and apoptosis act in the development of SAE. In the current study, we evaluated ... -
Melatonin protects the heart and endothelium against high fructose corn syrup consumption-induced cardiovascular toxicity via SIRT-1 signaling
Savran, Mehtap; Aşçı, Halil; Özmen, Özlem; Erzurumlu, Yalçın; Savaş, Hasan Basri; Sönmez, Yasin; Şahin, Yasemin (Sage Publications Ltd, 2019)High fructose corn syrup (HFCS) has been shown to cause cardiovascular toxicity via oxidative stress and inflammation. The aim of this study is to demonstrate the protective effects of melatonin (MLT) against HFCS-induced ...
